Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25299
Title: Normative values for SedLine-based processed electroencephalography parameters in awake volunteers: a prospective observational study.
Austin Authors: Belletti, Alessandro;Naorungroj, Thummaporn ;Yanase, Fumitaka ;Eastwood, Glenn M ;Weinberg, Laurence ;Bellomo, Rinaldo 
Affiliation: Data Analytics Research and Evaluation (DARE) Centre
Anaesthesia
Department of Surgery, The University of Melbourne, Melbourne, VIC, Australia
Department of Medicine, The University of Melbourne, Melbourne, VIC, Australia
Intensive Care
Department of Intensive Care, Siriraj Hospital, Mahidol University, Bangkok, Thailand..
Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy..
Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia
Issue Date: 11-Nov-2020
metadata.dc.date: 2020-11-11
Publication information: Journal of Clinical Monitoring and Computing 2020; online first: 11 November
Abstract: Processed electroencephalography (pEEG) is used to monitor depth of anaesthesia and/or sedation. A novel device (SedLine®) has been recently introduced into clinical practice. However, there are no published data on baseline SedLine values for awake adult subjects. We aimed to determine baseline values for SedLine-derived parameters in eyes-open and eyes-closed states. We performed a prospective observational study in healthy volunteers. SedLine EEG-derived parameters were recorded for 2 min with eyes closed and 8 min with eyes open. We determined the overall reference range for each value, as well as the reference range in each phase. We investigated changes in recorded parameters between the two phases, and the interaction between EMG, baseline characteristics, and Patient State Index (PSI). We collected data from 50 healthy volunteers, aged 23-63 years. Median PSI was 94 (92-95) with eyes open and 88 (87-91) with eyes closed (p < 0.001 for open versus close). EMG activity decreased from 47.2% (46.6-47.9) with eyes open to 28.6% (28.0-29.3) with eyes closing (p < 0.001). There was a significant positive correlation between EMG and PSI with eyes closed (p = 0.01) but not with eyes open, which was confirmed with linear regression analysis (p = 0.01). In awake volunteers, keeping eyes open induces significant changes to SedLine-derived parameters, most likely due to increased EMG activity (e.g. eye blinking). These findings have implications for the clinical interpretation of PSI parameters and for the planning of future research.
URI: https://ahro.austin.org.au/austinjspui/handle/1/25299
DOI: 10.1007/s10877-020-00618-4
ORCID: 0000-0003-3131-0565
PubMed URL: 33175254
Type: Journal Article
Subjects: Anaesthesia
Awareness
Electroencephalogram
Neuromonitoring
Sedation
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