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https://ahro.austin.org.au/austinjspui/handle/1/25153| Title: | Automated radiosynthesis of [68 Ga]Ga-PSMA-11 and [177 Lu]Lu-PSMA-617 on the iPHASE MultiSyn module for clinical applications. | Austin Authors: | Wichmann, Christian W;Ackermann, Uwe ;Poniger, Stan ;Young, Kenneth ;Nguyen, Benjamin;Chan, Gordon;Sachinidis, John;Scott, Andrew M | Affiliation: | Department of Medicine, University of Melbourne, Parkville, VIC, Australia Olivia Newton-John Cancer Research Institute School of Cancer Medicine, La Trobe University, Bundoora, VIC, Australia Molecular Imaging and Therapy |
Issue Date: | 2021 | Date: | 2020-10-17 | Publication information: | Journal of labelled compounds & radiopharmaceuticals 2021; 64(3): 140-146 | Abstract: | PSMA-targeted imaging and therapy of prostate cancer using theranostic pairs is rapidly changing clinical practice. To facilitate clinical trials, fully automated procedures for the radiosyntheses of [68 Ga]Ga-PSMA-11 and [177 Lu]Lu-PSMA-617 were developed from commercially available precursors using the cassette based iPHASE MultiSyn module. Formulated and sterile radiopharmaceuticals were obtained in 76 ± 3% (n = 20) and 91 ± 4% (n = 15) radiochemical yields after 17 and 20 minutes, respectively. Radiochemical purity was always > 95% and molar activities exceeded 792 ± 100 GBq/μmol and 88 ± 6 GBq/μmol, respectively. Quality control showed conformity with all relevant release criteria and radiopharmaceuticals were used in the clinic. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/25153 | DOI: | 10.1002/jlcr.3889 | ORCID: | 0000-0001-5341-8804 | Journal: | Journal of Labelled Compounds & Radiopharmaceuticals | PubMed URL: | 33067810 | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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