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Title: Comorbidity of Cerebrovascular and Alzheimer's Disease in Aging.
Austin Authors: Xia, Ying;Yassi, Nawaf;Raniga, Parnesh;Bourgeat, Pierrick;Desmond, Patricia;Doecke, James;Ames, David;Laws, Simon M;Fowler, Christopher;Rainey-Smith, Stephanie R;Martins, Ralph;Maruff, Paul;Villemagne, Victor L ;Masters, Colin L ;Rowe, Christopher C ;Fripp, Jurgen;Salvado, Olivier
Affiliation: Cog State Ltd, Melbourne, VIC, Australia
Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, WA, Australia
Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Medicine (University of Melbourne)
Molecular Imaging and Therapy
The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia
CSIRO Data61, Brisbane, QLD, Australia
School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, WA, Australia
Academic Unit for Psychiatry of Old Age, University of Melbourne, Parkville, VIC, Australia
National Ageing Research Institute, Parkville, VIC, Australia
Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia
Department of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia
The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, QLD, Australia
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
Issue Date: 27-Oct-2020 2020-09-19
Publication information: Journal of Alzheimer's Disease : JAD 2020; 78(1): 321-334
Abstract: Cerebrovascular disease often coexists with Alzheimer's disease (AD). While both diseases share common risk factors, their interrelationship remains unclear. Increasing the understanding of how cerebrovascular changes interact with AD is essential to develop therapeutic strategies and refine biomarkers for early diagnosis. We investigate the prevalence and risk factors for the comorbidity of amyloid-β (Aβ) and cerebrovascular disease in the Australian Imaging, Biomarkers and Lifestyle Study of Ageing, and further examine their cross-sectional association. A total of 598 participants (422 cognitively normal, 89 with mild cognitive impairment, 87 with AD) underwent positron emission tomography and structural magnetic resonance imaging for assessment of Aβ deposition and cerebrovascular disease. Individuals were categorized based on the comorbidity status of Aβ and cerebrovascular disease (V) as Aβ-V-, Aβ-V+, Aβ+V-, or Aβ+V+. Advancing age was associated with greater likelihood of cerebrovascular disease, high Aβ load and their comorbidity. Apolipoprotein E ɛ4 carriage was only associated with Aβ positivity. Greater total and regional WMH burden were observed in participants with AD. However, no association were observed between Aβ and WMH measures after stratification by clinical classification, suggesting that the observed association between AD and cerebrovascular disease was driven by the common risk factor of age. Our observations demonstrate common comorbid condition of Aβ and cerebrovascular disease in later life. While our study did not demonstrate a convincing cross-sectional association between Aβ and WMH burden, future longitudinal studies are required to further confirm this.
DOI: 10.3233/JAD-200419
PubMed URL: 32986666
Type: Journal Article
Subjects: Alzheimer’s disease
cerebrovascular disease
white matter hyperintensities
Appears in Collections:Journal articles

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