Please use this identifier to cite or link to this item:
Title: Pilot Study of Patients' Preferences for Immediate Resection Versus a Watch and Wait Approach After Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer.
Austin Authors: Gunjur, Ashray ;Chazan, Grace;Newnham, Genni;McLachlan, Sue-Anne
Affiliation: Medical Oncology
Peter MacCallum Cancer Centre, Melbourne, NSW, Australia
Oncology and Cancer Services, St Vincent's Hospital Melbourne, Melbourne, NSW, Australia
Department of Medicine, University of Melbourne, Melbourne, NSW, Australia
Issue Date: Feb-2021
Date: 2020-09-14
Publication information: JCO Oncology Practice 2021; 17(2): e149-e157
Abstract: In patients with rectal cancer who achieve a clinical complete response to neoadjuvant chemoradiation, it may be reasonable to adopt a watch-and-wait (W&W) strategy rather than proceed to immediate resection of the rectum. Patient preferences for this strategy are unknown. The primary aim of the current study was to determine the feasibility of assessing hypothetical recurrence and survival differences that relevant patients would tolerate to avoid immediate resection of the rectum. A secondary aim included estimating patients' tolerance thresholds and the factors that might predict them. We developed a study-specific written questionnaire based on a previously validated instrument. Hypothetical time tradeoff tasks were used to determine the recurrence rate patients would accept to adopt a W&W strategy and the survival benefit that would be needed to justify choosing immediate resection over W&W. Feasibility was measured on the basis of response rate, the stated ease of completion and the satisfaction of task, and time used. Twenty of 31 potentially eligible patients completed the study-specific questionnaire. The majority of respondents felt that questions were clear (70%) and not hard to understand (65%). The median acceptable response rate to adopt a W&W strategy was 20% (interquartile range [IQR], 10%-35%). Patients required a median of 2.0 extra years of survival (IQR, 1.0-3.0 years) over a baseline 7.0 years, and they required a median extra 10% (IQR, 4%-19%) over baseline 70% survival rates to justify immediate resection. Measuring the preferences of patients with rectal cancer using time tradeoff methods seemed to be feasible. Larger studies are needed to confirm how acceptable a W&W strategy would be for relevant patients.
DOI: 10.1200/OP.20.00158
Journal: JCO Oncology Practice
PubMed URL: 32926663
Type: Journal Article
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Apr 17, 2024

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.