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Title: Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction.
Austin Authors: Kaitu'u-Lino, Tu'uhevaha J;MacDonald, Teresa M;Cannon, Ping;Nguyen, Tuong-Vi;Hiscock, Richard J;Haan, Nick;Myers, Jenny E;Hastie, Roxanne;Dane, Kirsten M;Middleton, Anna L;Bittar, Intissar ;Sferruzzi-Perri, Amanda N;Pritchard, Natasha;Harper, Alesia;Hannan, Natalie J;Kyritsis, Valerie;Crinis, Nick ;Hui, Lisa ;Walker, Susan P;Tong, Stephen
Affiliation: Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, 3084, Victoria, Australia
Mercy Perinatal, Mercy Hospital for Women, Heidelberg, 3084, Victoria, Australia
Foresight Health, Adelaide, 169 Fullarton Rd., Dulwich, 5065, South Australia, Australia
University of Manchester, Manchester Academic Health Science Centre, St Mary's Hospital, Manchester, M13, OJH, UK
Mercy Hospital for Women, Heidelberg
Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK
Issue Date: 15-May-2020 2020-05-15
Publication information: Nature Communications 2020; 11(1): 2411
Abstract: Placental insufficiency can cause fetal growth restriction and stillbirth. There are no reliable screening tests for placental insufficiency, especially near-term gestation when the risk of stillbirth rises. Here we show a strong association between low circulating plasma serine peptidase inhibitor Kunitz type-1 (SPINT1) concentrations at 36 weeks' gestation and low birthweight, an indicator of placental insufficiency. We generate a 4-tier risk model based on SPINT1 concentrations, where the highest risk tier has approximately a 2-5 fold risk of birthing neonates with birthweights under the 3rd, 5th, 10th and 20th centiles, whereas the lowest risk tier has a 0-0.3 fold risk. Low SPINT1 is associated with antenatal ultrasound and neonatal anthropomorphic indicators of placental insufficiency. We validate the association between low circulating SPINT1 and placental insufficiency in two other cohorts. Low circulating SPINT1 is a marker of placental insufficiency and may identify pregnancies with an elevated risk of stillbirth.
DOI: 10.1038/s41467-020-16346-x
ORCID: 0000-0001-9099-7745
PubMed URL: 32415092
Type: Journal Article
Appears in Collections:Journal articles

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