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Title: Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer's Disease Patients and Correlates with Cognitive Performance.
Austin Authors: Pedrini, Steve;Hone, Eugene;Gupta, Veer B;James, Ian;Teimouri, Elham;Bush, Ashley I;Rowe, Christopher C ;Villemagne, Victor L ;Ames, David;Masters, Colin L ;Rainey-Smith, Stephanie;Verdile, Giuseppe;Sohrabi, Hamid R;Raida, Manfred R;Wenk, Markus R;Taddei, Kevin;Chatterjee, Pratishtha;Martins, Ian;Laws, Simon M;Martins, Ralph N
Affiliation: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
CRC for Mental Health, Carlton South, Victoria, Australia
Life Science Institute, Singapore Lipidomics Incubator, National University of Singapore, Singapore
School of Biomedical Sciences, Curtin University, Bentley, WA, Australia
University of Melbourne Academic unit for Psychiatry of Old Age, St George's Hospital, Kew, Victoria, Australia
National Ageing Research Institute, Parkville, Victoria, Australia
Molecular Imaging and Therapy
Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, WA, Australia
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia
Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia
Centre for Healthy Ageing, School of Psychology and Exercise Science, Murdoch University, Murdoch WA, Australia
School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia
The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia
Issue Date: 2020 2020-07-24
Publication information: Journal of Alzheimer's disease : JAD 2020; 77(2): 733-744
Abstract: The link between cholesterol and Alzheimer's disease (AD) has received much attention, as evidence suggests high levels of cholesterol might be an AD risk factor. The carriage of cholesterol and lipids through the body is mediated via lipoproteins, some of which, particularly apolipoprotein E (ApoE), are intimately linked with AD. In humans, high density lipoprotein (HDL) is regarded as a "good" lipid complex due to its ability to enable clearance of excess cholesterol via 'cholesterol reverse transport', although its activities in the pathogenesis of AD are poorly understood. There are several subclasses of HDL; these range from the newly formed small HDL, to much larger HDL. We examined the major subclasses of HDL in healthy controls, mild cognitively impaired, and AD patients who were not taking statins to determine whether there were HDL profile differences between the groups, and whether HDL subclass levels correlated with plasma amyloid-β (Aβ) levels or brain Aβ deposition. Samples from AIBL cohort were used in this study. HDL subclass levels were assessed by Lipoprint while Aβ1-42 levels were assessed by ELISA. Brain Aβ deposition was assessed by PET scan. Statistical analysis was performed using parametric and non-parametric tests. We found that small HDL subclass is reduced in AD patients and it correlates with cognitive performance while plasma Aβ concentrations do not correlate with lipid profile or HDL subfraction levels. Our data indicate that AD patients exhibit altered plasma HDL profile and that HDL subclasses correlate with cognitive performances.
DOI: 10.3233/JAD-200291
Journal: Journal of Alzheimer's disease : JAD
PubMed URL: 32741823
Type: Journal Article
Subjects: Amyloid-β
lipid transport
Appears in Collections:Journal articles

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