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Title: Aggregation of Abnormal Memory Scores and Risk of Incident Alzheimer's Disease Dementia: A Measure of Objective Memory Impairment in Amnestic Mild Cognitive Impairment.
Austin Authors: Bradfield, Nicholas I;Ellis, Kathryn A;Savage, Greg;Maruff, Paul;Burnham, Samantha;Darby, David;Lautenschlager, Nicola T;Martins, Ralph N;Masters, Colin L ;Rainey-Smith, Stephanie R;Robertson, Joanne;Rowe, Christopher C ;Woodward, Michael M ;Ames, David
Affiliation: The Florey Institute of Neurosciences and Mental Health, Parkville, Victoria, Australia
Molecular Imaging and Therapy
Florey Institute, The University of Melbourne, Victoria, Australia
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia
NorthWestern Mental Health, Melbourne Health, Parkville, Victoria, Australia
Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia
Department of Psychology, Macquarie University, Sydney, NSW, Australia
St Vincent's Hospital, Fitzroy, Victoria, Australia
National Ageing Research Institute, Parkville, Victoria, Australia
Geriatric Medicine
CSIRO, Parkville, Victoria, Australia
Cogstate Pty Ltd, Melbourne, Victoria, Australia
Issue Date: Feb-2021
Date: 2020-08-10
Publication information: Journal of the International Neuropsychological Society : JINS 2021; 27(2): 146-157
Abstract: The criteria for objective memory impairment in mild cognitive impairment (MCI) are vaguely defined. Aggregating the number of abnormal memory scores (NAMS) is one way to operationalise memory impairment, which we hypothesised would predict progression to Alzheimer's disease (AD) dementia. As part of the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing, 896 older adults who did not have dementia were administered a psychometric battery including three neuropsychological tests of memory, yielding 10 indices of memory. We calculated the number of memory scores corresponding to z ≤ -1.5 (i.e., NAMS) for each participant. Incident diagnosis of AD dementia was established by consensus of an expert panel after 3 years. Of the 722 (80.6%) participants who were followed up, 54 (7.5%) developed AD dementia. There was a strong correlation between NAMS and probability of developing AD dementia (r = .91, p = .0003). Each abnormal memory score conferred an additional 9.8% risk of progressing to AD dementia. The area under the receiver operating characteristic curve for NAMS was 0.87 [95% confidence interval (CI) .81-.93, p < .01]. The odds ratio for NAMS was 1.67 (95% CI 1.40-2.01, p < .01) after correcting for age, sex, education, estimated intelligence quotient, subjective memory complaint, Mini-Mental State Exam (MMSE) score and apolipoprotein E ϵ4 status. Aggregation of abnormal memory scores may be a useful way of operationalising objective memory impairment, predicting incident AD dementia and providing prognostic stratification for individuals with MCI.
DOI: 10.1017/S135561772000079X
ORCID: 0000-0002-3340-5296
Journal: Journal of the International Neuropsychological Society : JINS
PubMed URL: 32772959
Type: Journal Article
Subjects: Cognitive ageing
Cognitive neuroscience
Mild neurocognitive disorder
Neurocognitive disorders
Appears in Collections:Journal articles

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