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Title: Early Treatment with Human Albumin Solution in Continuous Renal Replacement Patients.
Austin Authors: O'Brien, Zachary ;Finnis, Mark;Gallagher, Martin;Bellomo, Rinaldo 
Affiliation: The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia
Department of Intensive Care, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Intensive Care
Issue Date: 20-Aug-2020 2021
Publication information: Blood Purification 2021; 50(2): 205-213
Abstract: To study the impact of early human albumin solution (HAS) in continuous renal replacement therapy (RRT) patients. Analysis of Randomized Evaluation of Normal versus Augmented Level (RENAL) RRT trial data. Of 1,464 patients, 500 (34%) received early albumin. These patients had higher illness severity scores, greater use of mechanical ventilation, and 90-day mortality (51 vs. 41%; p < 0.001). However, early albumin carried similar RRT dependence risk among survivors at day 90 (4.9 vs. 5.8%; p = 0.62). On Cox proportional hazards regression, with standardized inverse probability of treatment weighting, early albumin was not associated with increased mortality (hazard ratio [HR]: 1.23, 95% CI: 0.97-1.55; p = 0.09) or recovery to RRT independence (HR: 0.92, 95% CI: 0.78-1.10; p = 0.38). Early albumin was administered to one-third of RENAL trial patients and in those with greater illness severity. Early albumin was not independently associated with mortality risk or rate of recovery to RRT independence.
DOI: 10.1159/000509890
PubMed URL: 32818931
Type: Journal Article
Subjects: Acute kidney injury
Continuous renal replacement therapy
Appears in Collections:Journal articles

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