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Title: Neurotrophins as a reliable biomarker for brain function, structure and cognition: A systematic review and meta-analysis.
Austin Authors: McPhee, Grace M;Downey, Luke A;Stough, Con
Affiliation: Institute for Breathing and Sleep
Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia
Issue Date: Nov-2020
Date: 2020-08-18
Publication information: Neurobiology of Learning and Memory 2020; 175: 107298
Abstract: Neurotrophins are signalling molecules involved in the formation and maintenance of synapses in the brain. They can cross the blood-brain barrier and be detected in peripheral blood, suggesting they may be a potential biomarker for brain health and function. In this review, the available literature was systematically searched for studies comparing peripheral neurotrophins levels with MRI and cognitive measures in healthy adults. Twenty-four studies were identified, six of which included a neuroimaging outcome. Fifteen studies measuring cognition were eligible for meta-analysis. The majority of studies measured levels of brain-derived neurotrophic factor (BDNF), with few assessing other neurotrophins. Results revealed BDNF is related to some neuroimaging outcomes, with some studies suggesting older age may be an important factor. A higher proportion of studies who had older samples observed significant effects between cognition and neurotrophin levels. When cognitive studies were pooled together in a meta-analysis, there was a weak non-significant effect between BDNF and cognitive outcomes. There was also a high level of heterogeneity between cognitive studies. Results indicated that gender was a notable source of the heterogeneity, but additional studies employing relevant covariates are necessary to better characterise the inter-relationship between circulating neurotrophins and cognition.
DOI: 10.1016/j.nlm.2020.107298
Journal: Neurobiology of Learning and Memory
PubMed URL: 32822863
Type: Journal Article
Subjects: Brain structure
Healthy adults
Neurotrophic factors
Peripheral biomarkers
Appears in Collections:Journal articles

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