Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/24443
Title: Diversity in the intrinsic apoptosis pathway of nematodes.
Austin Authors: Young, Neil D;Harris, Tiffany J ;Evangelista, Marco;Tran, Sharon;Wouters, Merridee A;Soares da Costa, Tatiana P;Kershaw, Nadia J;Gasser, Robin B;Smith, Brian J;Lee, Erinna F;Fairlie, Walter Douglas 
Affiliation: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia
La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia
ProCanĀ®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia
School of Cancer Medicine, La Trobe University, Melbourne, VIC, 3084, Australia
Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia
The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia
Issue Date: 28-Aug-2020
Date: 2020
Publication information: Communications Biology 2020; 3(1): 478
Abstract: Early studies of the free-living nematode C. elegans informed us how BCL-2-regulated apoptosis in humans is regulated. However, subsequent studies showed C. elegans apoptosis has several unique features compared with human apoptosis. To date, there has been no detailed analysis of apoptosis regulators in nematodes other than C. elegans. Here, we discovered BCL-2 orthologues in 89 free-living and parasitic nematode taxa representing four evolutionary clades (I, III, IV and V). Unlike in C. elegans, 15 species possess multiple (two to five) BCL-2-like proteins, and some do not have any recognisable BCL-2 sequences. Functional studies provided no evidence that BAX/BAK proteins have evolved in nematodes, and structural studies of a BCL-2 protein from the basal clade I revealed it lacks a functionally important feature of the C. elegans orthologue. Clade I CED-4/APAF-1 proteins also possess WD40-repeat sequences associated with apoptosome assembly, not present in C. elegans, or other nematode taxa studied.
URI: https://ahro.austin.org.au/austinjspui/handle/1/24443
DOI: 10.1038/s42003-020-01208-5
ORCID: 0000-0001-8756-229X
0000-0002-2121-912X
0000-0002-4423-1690
0000-0003-0498-1910
0000-0003-1255-9808
0000-0002-2498-1160
Journal: Communications Biology
PubMed URL: 32859965
Type: Journal Article
Appears in Collections:Journal articles

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