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Title: Identification and management of congenital parvovirus B19 infection.
Austin Authors: Attwood, Lucy O;Holmes, Natasha E ;Hui, Lisa 
Affiliation: Department of Perinatal Medicine, Mercy Hospital for Women, Melbourne, Australia
Infectious Diseases
Department of Obstetrics and Gynaecology, Northern Health
Reproductive Epidemiology group, Murdoch Children's Research Institute
Department of Obstetrics and Gynaecology, The University of Melbourne, Australia
Department of Medicine and Radiology, The University of Melbourne, Australia
Issue Date: 29-Aug-2020 2020-08-29
Publication information: Prenatal Diagnosis 2020; online first: 29 August
Abstract: Parvovirus B19 (B19V) infection is well known for its mild, self-limiting clinical presentations in children, such as erythema infectiosum. Approximately 40% of women of childbearing age are susceptible to B19V infection. While maternal B19V infection usually has a good prognosis, B19V can cause severe fetal anaemia and pregnancy loss due to its ability to suppress erythroid progenitor cells. Noninvasive ultrasound monitoring for fetal anaemia is usually performed if maternal seroconversion occurs in the first 20 weeks of gestation, with amniocentesis for fetal infection reserved for those who first present with fetal anaemia or hydrops of unknown cause. Intrauterine transfusion is the standard treatment for severe fetal anaemia and is associated with a significant improvement in survival. However, survivors of hydrops fetalis may have a higher rate of long-term neurodevelopmental complications compared with nonhydropic survivors. This review aims to synthesise published data on the diagnosis, surveillance and outcomes of congenital parvovirus infection to assist clinicians in diagnosing and managing this important condition. This article is protected by copyright. All rights reserved.
DOI: 10.1002/pd.5819
ORCID: 0000-0003-0447-7917
PubMed URL: 32860469
Type: Journal Article
Appears in Collections:Journal articles

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