Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/23921
Title: Statin intolerance: an updated, narrative review mainly focusing on muscle adverse effects.
Austin Authors: Li, Jian-Jun;Liu, Hui-Hui;Wu, Na-Qiong;Yeo, Khung Keong;Tan, Kathyrn;Ako, Junya;Krittayaphong, Rungroj;Tan, Ru San;Aylward, Philip E;Baek, Sang Hong;Dalal, Jamshed;Fong, Alan Yean Yip;Li, Yi-Heng;O'Brien, Richard C ;Lim, Tien Siang Eric;Koh, Si Ya Natalie;Scherer, Daniel J;Tada, Hayato;Kang, Vernon;Butters, Julie;Nicholls, Stephen J
Affiliation: Kokilaben Hospital , Mumbai, India
State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College , BeiLiShi Road 167, Beijing 100037, China
South Australian Health and Medical Research Institute and Flinders University, Adelaide, Australia
State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing 100037, China
Monash Cardiovascular Research Centre, Victorian Heart Institute, Monash University, Melbourne, Australia
Austin Health Clinical School, The University of Melbourne, Heidelberg, Victoria, Australia
State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College , BeiLiShi Road 167, Beijing 100037, China
National Heart Centre and SingHealth Duke-NUS Cardiovascular Sciences , Singapore
Department of Medicine, University of Hong Kong
Kitasato University, Sagamihara, Japan
Division of Cardiology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
National Heart Centre and SingHealth Duke-NUS Cardiovascular Sciences, Singapore
Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Korea
Department of Cardiology, Sarawak Heart Centre; and Clinical Research Centre, Sarawak General Hospital, Kuching, Malaysia
National Cheng Kung University Hospital, Tainan, Taiwan
National Heart Centre and SingHealth Duke-NUS Cardiovascular Sciences, Singapore
South Australian Health and Medical Research Institute
Kanazawa University Graduate School of Medicine, Kanazawa, Japan
Singapore Heart Foundation, Singapore
Issue Date: Sep-2020
metadata.dc.date: 2020-07-30
Publication information: Expert Opinion on Drug Metabolism & Toxicology 2020; 16(9): 837-851
Abstract: Statins have been established as the standard of care for dyslipidemia and preventing cardiovascular diseases while posing few safety concerns. However, misconceptions about statin intolerance lead to their underuse, indicating a need to improve the understanding of the safety of this treatment. We searched PubMed and reviewed literatures related to statin intolerance published between February 2015 and February 2020. Important large-scale or landmark studies published before 2015 were also cited as key evidence. Optimal lowering of low-density lipoprotein cholesterol with statins substantially reduces the risk of cardiovascular events. Muscle adverse events (AEs) were the most frequently reported AEs by statin users in clinical practice, but they usually occurred at a similar rate with statins and placebo in randomized controlled trials and had a spurious causal relationship with statin treatment. We proposed a rigorous definition for identifying true statin intolerance and present the criteria for defining different forms of muscle AEs and an algorithm for their management. True statin intolerance is uncommon, and every effort should be made to exclude false statin intolerance and ensure optimal use of statins. For the management of statin intolerance, statin-based approaches should be prioritized over non-statin approaches.
URI: http://ahro.austin.org.au/austinjspui/handle/1/23921
DOI: 10.1080/17425255.2020.1802426
PubMed URL: 32729743
Type: Journal Article
Subjects: Cardiovascular disease
Definition
Dyslipidemia
Management
Mechanism
Muscle toxicity
Nonstatin
Statin
Statin intolerance
Appears in Collections:Journal articles

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