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Title: Tissue response to a chronically implantable wireless, intracortical visual prosthesis (Gennaris array).
Austin Authors: Rosenfeld, Jeffrey V;Wong, Yan Tat;Yan, Edwin;Szlawski, Julian;Mohan, Anand;Clark, Jonathan C M;Rosa, Marcello;Lowery, Arthur
Affiliation: Department of Neurosurgery, The Alfred, Commercial Road, Melbourne Vic 3004, Melbourne, Victoria, 3004, Australia
Electrical and Computer System Engineering, Monash University, Clayton, Victoria, Australia
Electrical and Computer Systems Engineering, Monash University, Clayton, Victoria, Australia
Department of Physiology and Department of Electrical and Computer System Engineering, Monash University, Melbourne, Victoria, Australia
Department of Physiology, Monash University, Monash, Victoria, Australia
Austin Pathology, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 10-Jul-2020 2020-06-18
Publication information: Journal of neural engineering 2020; 17(4): 046001
Abstract: Cortical vision prostheses aim to restore visual percepts to those who have lost sight by delivering electrical stimulation to the visual cortex. These devices need to be implanted intracranially using subdural or intracortical microelectrodes, and should preferably dispense with the need of transcranial wiring. The risks of cortical tissue injury from mechanical trauma, material biocompatibility, heat generation, electrical stimulation and long-term immune responses need to be evaluated. In this paper, we investigate the biological response to a wireless cortical vision prosthesis (Gennaris array), by characterizing the histological changes that occur following chronic electrical stimulation. Ten arrays (7 active, 3 passive) were implanted in three sheep using a pneumatic insertor. Each device consisted of a wireless receiver and Application Specific Integrated Circuit encased in a ceramic box, and could deliver electrical stimulation through one of 43 electrodes. Stimulation was delivered through seven of these devices for up to 3 months and each device was treated as independent for further analysis. Cumulatively, over 2,700 hours of stimulation were achieved without any observable adverse health effects. Histology showed that the devices and implantation procedure were well tolerated by the brain with a similar tissue response to the more common Utah arrays. However, voltage transients across the stimulating electrodes were not measured so exact charge injection could not be verified. This work represents one of the first long-term tests of a fully implantable cortical vision prosthesis. The results indicate that long-term stimulation through wireless arrays can be achieved without induction of widespread tissue damage.
DOI: 10.1088/1741-2552/ab9e1c
ORCID: 0000-0002-5281-8221
PubMed URL: 32554869
Type: Journal Article
Subjects: brain machine interfaces
chronic electrical stimulation
cortical vision prosthesis
tissue response
vision prosthesis
Appears in Collections:Journal articles

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