Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/23584
Title: Features of intracranial hemorrhage in cerebral venous thrombosis.
Austin Authors: Afifi, K;Bellanger, G;Buyck, P J;Zuurbier, S M;Esperon, C G;Barboza, M A;Costa, P;Escudero, I;Renard, D;Lemmens, R;Hinteregger, N;Fazekas, F;Conde, J Jimenez;Giralt-Steinhauer, E;Hiltunen, S;Arauz, A;Pezzini, A;Montaner, J;Putaala, J;Weimar, C;Schlamann, Marc;Gattringer, T;Tatlisumak, T;Coutinho, J M;Demaerel, P;Thijs, Vincent N 
Affiliation: Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, Australia
Department of Clinical Neuroscience/Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden
Neurovascular Lab, Instituto de Biomedicina de Sevilla, Sevilla, Spain
Universitat Autònoma de Barcelon, Barcelona, Spain
Department of Clinical and Experimental Sciences, Neurology Clinic University of Brescia, Brescia, Italy
Department of Neurology, Hospital Universitario Virgen Macarena, Seville, Spain..
Department of Neurology, Neurovascular Research Group, IMIM-Hospital del Mar, Barcelona, Spain
Universitat Autònoma de Barcelon, Barcelona, Spain
Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven-University of Leuven, Leuven, Belgium
Laboratory of Neurobiology, Center for Brain and Disease Research, VIB, Leuven, Belgium
Department of Neurology, University Hospitals Leuven, Leuven, Belgium
Neurology Department, University Hospital Virgen del Rocio, Sevilla, Spain
Neurovascular Lab, Instituto de Biomedicina de Sevilla, Sevilla, Spain
Department of Neurology, Menoufia University, Al Minufya, Menoufia, Egypt
Stroke Division, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Neuroradiology, Purpan University Hospital, Toulouse, France
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia
Department of Head and Neck, Neurology Clinic, University of Brescia, Brescia, Italy
Department of Neurology, Helsinki University Hospital, Helsinki, Finland
Department of Radiology, University Hospitals Leuven, Leuven, Belgium
Department of Neurology, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands
Stroke Department, Instituto Nacional de Neurología Y Neurocirugía Dr. Manuel Velasco Suárez, México City, México
Department of Neurology, Nîmes University Hospital, Nîmes, France
Department of Radiology, Division of Neuroradiology, Vascular and Interventional Radiology, Medical University of Graz, Graz, Austria
Department of Neurology, Medical University of Graz, Graz, Austria
Department of Neurology, Helsinki University Hospital, Helsinki, Finland
Stroke Department, Instituto Nacional de Neurología Y Neurocirugía Dr. Manuel Velasco Suárez, México City, México
Department of Neurology, Helsinki University Hospital, Helsinki, Finland
Department of Neurology, University Hospital Essen, Essen, Germany
Institute for Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany
Department of Radiology, Division of Neuroradiology, Vascular and Interventional Radiology, Medical University of Graz, Graz, Austria..
Department of Neurology, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands
Department of Radiology, University Hospitals Leuven, Leuven, Belgium
Issue Date: Nov-2020
metadata.dc.date: 2020-06-22
Publication information: Journal of Neurology 2020; 267(11): 3292-3298
Abstract: Cerebral venous thrombosis (CVT) is associated with intracranial hemorrhage. To identify clinical and imaging features of CVT-associated intracranial hemorrhage. We hypothesized that higher clot burden would be associated with a higher risk of intracranial hemorrhage. We performed a retrospective analysis of an international, multicenter cohort of patients with confirmed cerebral venous thrombosis who underwent computed tomography within 2 weeks of symptom onset. Clinical and imaging features were compared between patients with and without intracranial hemorrhage. Clot burden was assessed by counting the number of thrombosed venous sinuses and veins on confirmatory imaging. We enrolled 260 patients from 10 institutions in Europe and Mexico. The mean age was 42 years and 74% were female. Intracranial hemorrhage was found in 102 (39%). Among them parenchymal hemorrhage occurred in 64 (63%), in addition, small juxta-cortical hemorrhage was found in 30 (29%), subarachnoid hemorrhage in 24 (24%) and subdural hemorrhage in 11 (11%). Multiple concomitant types of hemorrhage occurred in 23 (23%). Older age and superior sagittal thrombosis involvement were associated with presence of hemorrhage. The number of thrombosed venous sinuses was not associated with intracranial hemorrhage (median number IQRInterquartile ratio] of sinuses/veins involved with hemorrhage 2 (1-3) vs. 2 (1-3) without hemorrhage, p = 0.4). The high rate of intracranial hemorrhage in cerebral venous thrombosis is not explained by widespread involvement of the venous sinuses. Superior sagittal sinus involvement is associated with higher bleeding risk.
URI: http://ahro.austin.org.au/austinjspui/handle/1/23584
DOI: 10.1007/s00415-020-10008-0
ORCID: 0000-0002-6767-2464
0000-0002-6614-8417
PubMed URL: 32572620
Type: Journal Article
Subjects: Bleeding.
Cerebral venous thrombosis
Hemorrhage
Stroke
Appears in Collections:Journal articles

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