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|Title:||Energy-dense vs routine enteral nutrition in New Zealand Europeans, Māori, and Pacific Peoples who are critically ill.|
|Authors:||Reid, Alice L;Chapman, Marianne J;Peake, Sandra L;Bellomo, Rinaldo;Davies, Andrew;Deane, Adam M;Horowitz, Michael;Hurford, Sally;Lange, Kylie;Little, Lorraine;Mackle, Diane;O'Connor, Stephanie N;Ridley, Emma J;Williams, Patricia J;Young, Paul J|
|Affiliation:||Research Fellow, Medical Research Institute of New Zealand, Wellington..|
Adjunct Research Fellow, Department of Epidemiology and Preventative Medicine, Monash University, VIC, Australia
ICU Clinical Research Manager, Royal Adelaide Hospital, Adelaide, SA, Australia
Affiliate Senior Lecturer, Acute Care Medicine, The University of Adelaide, SA, Australia
Research Coordinator, Department of Intensive Care Medicine, The Queen Elizabeth Hospital, Woodville South, SA, Australia
Affiliate Lecturer, Acute Care Medicine, The University of Adelaide, SA, Australia
Intensive Care Specialist, Intensive Care Unit, Frankston, VIC, Australia
Project Manager, School of Epidemiology and Preventive Medicine, Monash University, VIC, Australia
Biostatistician, Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, SA, Australia
Professor of Medicine & Head Endocrine Unit, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia
Senior Research Fellow, Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia
Principal Research Fellow, The University of Melbourne, Melbourne Medical School, Department of Medicine and Radiology, Royal Melbourne Hospital, Parkville, VIC, Australia
Intensive Care Unit, Austin Health, Heidelberg, Victoria, Australia
Research Director, Intensive Care Unit, Royal Adelaide Hospital, Adelaide, SA, Australia
Professor, Faculty of Health and Medical Sciences, The University of Adelaide, SA, Australia
Adjunct Associate Professor, School of Epidemiology and Preventive Medicine, Monash University, VIC, Australia
Director, Department of Intensive Care Medicine, The Queen Elizabeth Hospital, Woodville South, SA, Australia
Professor, Faculty of Health and Medical Sciences, University of Adelaide, SA, Australia
ICU Trials Project Manager, Medical Research Institute of New Zealand, Wellington..
ICU Programme Manager, Medical Research Institute of New Zealand, Wellington..
Deputy Director, Medical Research Institute of New Zealand, Wellington; Intensive Care Specialist, Wellington Hospital, Wellington..
|Citation:||The New Zealand medical journal 2020; 133(1516): 72-82|
|Abstract:||To evaluate the effect of energy-dense vs routine enteral nutrition on day-90 mortality by ethnic group in critically ill adults. Pre-planned subgroup analysis of the 1,257 New Zealanders in a 4,000-participant randomised trial comparing energy-dense enteral nutrition (1.5kcal/mL) with routine enteral nutrition (1kcal/mL) in mechanically ventilated intensive care unit (ICU) patients. The primary purpose of this analysis was to evaluate responses to study treatment by ethnic group (European, Māori, and Pacific Peoples) using ethnicity data recorded in the clinical records. The secondary purpose was to compare the characteristics and outcomes of patients by ethnic group. The primary outcome was day-90 mortality. Among 1,138 patients included in the primary outcome analysis, 165 of 569 (29.0%) assigned to energy-dense nutrition and 156 of 569 patients (27.4%) assigned to routine nutrition died by day 90 (odds ratio; 1.06; 95% CI, 0.92-1.22). There was no statistically significant interaction between treatment allocation and ethnicity with respect to day-90 mortality. Day-90 mortality rates did not vary statistically significantly by ethnic group. Among mechanically ventilated adults in New Zealand ICUs, the effect on day-90 mortality of energy-dense vs routine enteral nutrition did not vary by ethnicity.|
|Appears in Collections:||Journal articles|
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