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Title: Liver regeneration and liver metastasis.
Austin Authors: Riddiough, Georgina E ;Jalal, Qaiser;Perini, Marcos V ;Majeed, Ali W
Affiliation: Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Sheffield Teaching Hospitals, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, United Kingdom
Issue Date: 2021
Date: 2020-06-09
Publication information: Seminars in cancer biology 2021; 71: 86-97
Abstract: Surgical resection for primary and secondary hepatic neoplasms provides the best chance of cure. Advanced surgical techniques such as portal vein embolisation, two-staged hepatectomy and associated liver partition and portal vein ligation for staged-hepatectomy (ALPPS) have facilitated hepatic resection in patients with previously unresectable, bi-lobar disease. These techniques are frequently employed to ensure favourable clinical outcomes and avoid potentially fatal post-operative complications such as small for size syndrome and post-hepatectomy liver failure. However, they rely on the innate ability of the liver to regenerate. As our knowledge of liver organogenesis, liver regeneration and hepatocarcinogenesis has expanded in recent decades it has come to light that liver regeneration may also drive tumour recurrence. Clinical studies in patients undergoing portal vein embolisation indicate that tumours may progress following the procedure in concordance with liver regeneration and hypertrophy, however overall survival in these patients has not been shown to be worse. In this article, we delve into the mechanisms underlying liver regeneration to better understand the complex ways in which this may affect tumour behaviour and ultimately inform clinical decisions.
DOI: 10.1016/j.semcancer.2020.05.012
ORCID: 0000-0002-0165-1564
Journal: Seminars in cancer biology
PubMed URL: 32532594
Type: Journal Article
Subjects: Hepatic resection
Liver metastasis
Liver regeneration
Surgical oncology
Appears in Collections:Journal articles

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