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Title: Ischaemic heart disease and Cancer: competing malignant conditions.
Austin Authors: Murphy, Alexandra C ;Koshy, Anoop N ;Yudi, Matias B 
Affiliation: Department of Cardiology, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia
Issue Date: 27-May-2020 2020-05-27
Publication information: BMC cardiovascular disorders 2020; 20(1): 254
Abstract: The growing population of cancer survivors and their high frequency of cardiovascular disease have resulted in a dramatic increase in cancer patients requiring cardiovascular intervention. However, there is a lack of evidence to guide optimal management in this complex population who have historically been excluded from cardiovascular trials. We review the recently published meta-analysis by Roule et al. The findings of this analysis demonstrate that patients with cancer presenting with acute coronary syndrome (ACS) have increased rates of in-hospital cardiovascular mortality, bleeding and one-year cardiovascular mortality. All-cause mortality measured in-hospital and at one-year were also significantly greater in cancer patients as was all-cause mortality in cancer patients that undergo percutaneous coronary intervention (PCI). In contrast to the short-term outcomes, rates of long-term cardiovascular mortality did not differ significantly between groups. Patient-specific assessment of risk, accounting for disease characteristics and treatment, and close communication with oncology providers is vital in defining optimal treatment strategies in this population.
DOI: 10.1186/s12872-020-01539-5
ORCID: 0000-0002-3706-4150
PubMed URL: 32460710
Type: Journal Article
Appears in Collections:Journal articles

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