Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/23320
Title: The ENIGMA-Epilepsy working group: Mapping disease from large data sets.
Authors: Sisodiya, Sanjay M;Whelan, Christopher D;Hatton, Sean N;Huynh, Khoa;Altmann, Andre;Ryten, Mina;Vezzani, Annamaria;Caligiuri, Maria Eugenia;Labate, Angelo;Gambardella, Antonio;Ives-Deliperi, Victoria;Meletti, Stefano;Munsell, Brent C;Bonilha, Leonardo;Tondelli, Manuela;Rebsamen, Michael;Rummel, Christian;Vaudano, Anna Elisabetta;Wiest, Roland;Balachandra, Akshara R;Bargalló, Núria;Bartolini, Emanuele;Bernasconi, Andrea;Bernasconi, Neda;Bernhardt, Boris;Caldairou, Benoit;Carr, Sarah J A;Cavalleri, Gianpiero L;Cendes, Fernando;Concha, Luis;Desmond, Patricia M;Domin, Martin;Duncan, John S;Focke, Niels K;Guerrini, Renzo;Hamandi, Khalid;Jackson, Graeme D;Jahanshad, Neda;Kälviäinen, Reetta;Keller, Simon S;Kochunov, Peter;Kowalczyk, Magdalena A;Kreilkamp, Barbara A K;Kwan, Patrick;Lariviere, Sara;Lenge, Matteo;Lopez, Seymour M;Martin, Pascal;Mascalchi, Mario;Moreira, José C V;Morita-Sherman, Marcia E;Pardoe, Heath R;Pariente, Jose C;Raviteja, Kotikalapudi;Rocha, Cristiane S;Rodríguez-Cruces, Raúl;Seeck, Margitta;Semmelroch, Mira K H G;Sinclair, Benjamin;Soltanian-Zadeh, Hamid;Stein, Dan J;Striano, Pasquale;Taylor, Peter N;Thomas, Rhys H;Thomopoulos, Sophia I;Velakoulis, Dennis;Vivash, Lucy;Weber, Bernd;Yasuda, Clarissa Lin;Zhang, Junsong;Thompson, Paul M;McDonald, Carrie R
Affiliation: Department of Diagnostic and Interventional Neuroradiology, University Hospitals Tübingen, Tübingen, Germany
Florey Department of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia
Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, UK
Department of Neuropsychiatry, Royal Melbourne Hospital, Parkville, Victoria, Australia
Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK
Chalfont Centre for Epilepsy, Bucks, UK
Neuroscience Research Center, Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy
Institute of Neurology, University "Magna Graecia" of Catanzaro, Catanzaro, Italy
Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Neurology Unit, OCB Hospital, AOU Modena, Modena, Italy
Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, USA
Boston University School of Medicine, Boston, Massachusetts, USA
School of Pharmacy and Biomolecular Sciences, The Royal College of Surgeons in Ireland, Dublin, Ireland
FutureNeuro SFI Research Centre, Dublin, Ireland
Kuopio University Hospital, Member of EpiCARE ERN, Kuopio, Finland
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK
The Walton Centre, NHS Foundation Trust, Liverpool, UK
Pediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, Children's Hospital A. Meyer-University of Florence, Florence, Italy
Department of Neurology and Neuroimaging Laboratory, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil
Cleveland Clinic Neurological Institute, Cleveland, Ohio, USA
Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, Tübingen, Germany
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia
Department of Clinical Neurophysiology, University Hospital Göttingen, Goettingen, Germany
Pediatric Neurology and Muscular Diseases Unit, IRCCS Istituto 'G. Gaslini', Genova, Italy
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Italy
Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA
Department of Computer Science, University of North Carolina, Chapel Hill, North Carolina, USA
Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
Radiology Department of Center of Image Diagnosis, Hospital Clinic de Barcelona, Barcelona, Spain
Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia
The Wales Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK
Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico
Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec, Canada
Department of Neuroscience, Monash University, Melbourne, Victoria, Australia
Alfred Health, Melbourne, Victoria, Australia
Radiology and Research Administration, Henry Ford Health System, Detroit, Michigan, USA
School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran
Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland
Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, USA
Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK
UCL Queen Square Institute of Neurology, London, UK
Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
Neuroscience Research Center, Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy
Neuroscience Institute, University of Cape Town, Cape Town, South Africa
Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA
Neurology Unit, OCB Hospital, AOU Modena, Modena, Italy
Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Neurology Unit, USL Centro Toscana, Nuovo Ospedale Santo Stefano, Prato, Italy
Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada
McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada
Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada
Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, London, UK
Department of Neurology and Neuroimaging Laboratory, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico
Functional Imaging Unit, Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
University Medicine Göttingen, Clinical Neurophysiology, Göttingen, Germany
Pediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, Children's Hospital A. Meyer-University of Florence, Florence, Italy
Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA
McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada
Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK
Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, Tübingen, Germany
'Mario Serio' Department of Clinical and Experimental Medical Sciences, University of Florence, Florence, Italy
Department of Neurology and Neuroimaging Laboratory, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil
Department of Neurology, New York University School of Medicine, New York, New York, USA
Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
Department of Neurology and Neuroimaging Laboratory, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil
EEG and Epilepsy Unit, Geneva, Switzerland
South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Townon Risk & Resilience in Mental Disorders, Cape Town, South Africa
School of Computing, Newcastle University, Newcastle upon Tyne, UK
Institute of Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK
Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA
Institute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany
Department of Neurology and Neuroimaging Laboratory, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil
Cognitive Science Department, School of Informatics, Xiamen University, Xiamen, China
Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA
Department of Psychiatry, University of California San Diego, La Jolla, California, USA
Issue Date: 29-May-2020
EDate: 2020-05-29
Citation: Human brain mapping 2020; online first: 29 May
Abstract: Epilepsy is a common and serious neurological disorder, with many different constituent conditions characterized by their electro clinical, imaging, and genetic features. MRI has been fundamental in advancing our understanding of brain processes in the epilepsies. Smaller-scale studies have identified many interesting imaging phenomena, with implications both for understanding pathophysiology and improving clinical care. Through the infrastructure and concepts now well-established by the ENIGMA Consortium, ENIGMA-Epilepsy was established to strengthen epilepsy neuroscience by greatly increasing sample sizes, leveraging ideas and methods established in other ENIGMA projects, and generating a body of collaborating scientists and clinicians to drive forward robust research. Here we review published, current, and future projects, that include structural MRI, diffusion tensor imaging (DTI), and resting state functional MRI (rsfMRI), and that employ advanced methods including structural covariance, and event-based modeling analysis. We explore age of onset- and duration-related features, as well as phenomena-specific work focusing on particular epilepsy syndromes or phenotypes, multimodal analyses focused on understanding the biology of disease progression, and deep learning approaches. We encourage groups who may be interested in participating to make contact to further grow and develop ENIGMA-Epilepsy.
URI: http://ahro.austin.org.au/austinjspui/handle/1/23320
DOI: 10.1002/hbm.25037
ORCID: 0000-0002-9149-8726
0000-0002-9265-2393
0000-0002-2030-5552
0000-0002-8827-7324
0000-0001-7384-3074
0000-0003-0334-539X
0000-0002-8441-1485
0000-0003-2345-7938
0000-0002-6280-7526
0000-0001-6284-5402
0000-0002-5683-1941
0000-0001-9256-6041
0000-0001-9336-9568
0000-0001-5486-6289
0000-0001-7116-262X
0000-0002-7917-5326
0000-0001-5247-9795
0000-0002-5410-0299
0000-0001-6881-5191
0000-0003-2848-621X
0000-0002-8531-3916
0000-0003-4604-3367
0000-0002-2917-1212
0000-0002-7302-6856
0000-0002-6065-1476
0000-0002-0046-4070
PubMed URL: 32468614
Type: Journal Article
Review
Subjects: DTI
MRI
covariance
deep learning
event-based modeling
gene expression
genetics
imaging
quantitative
rsfMRI
Appears in Collections:Journal articles

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