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Title: Nivolumab resulting in persistently elevated troponin levels despite clinical remission of myocarditis and myositis in a patient with malignant pleural mesothelioma: case report.
Austin Authors: Lie, Gabrielle ;Weickhardt, Andrew;Kearney, Leighton G ;Lam, Que;John, Thomas ;Liew, David F L ;Arulananda, Surein
Affiliation: Department of Cardiology, Austin Health, Heidelberg, Victoria, Australia
Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia
Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, Austin Health, Heidelberg, Victoria, Australia
Department of Pathology, Austin Health, Heidelberg, Victoria, Australia
Cancer Immuno-Biology Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
School of Cancer Medicine, La Trobe University, Heidelberg, Australia
Department of Rheumatology, Austin Health, Heidelberg, Victoria, Australia
Issue Date: Apr-2020
Publication information: Translational lung cancer research 2020; 9(2): 360-365
Abstract: Malignant pleural mesothelioma (MPM) remains a deadly disease with limited therapeutic options beyond platinum/pemetrexed chemotherapy. Immune checkpoint inhibitors have demonstrated modest benefit in the second to later-line settings. An MPM patient from our institute developed myocarditis and myositis after 2 cycles of second-line nivolumab. Despite immunosuppression with corticosteroids and mycophenolate mofetil, there was ongoing rise in troponin levels which remained elevated for months. The patient developed an impressive but brief response following cessation of nivolumab. Myocarditis and myositis are rare complications of immune checkpoint inhibitors. Clinicians should be aware of these possible complications as myocarditis can result in mortality.
DOI: 10.21037/tlcr.2020.02.05
ORCID: 0000-0003-3399-5342
PubMed URL: 32420076
ISSN: 2218-6751
Type: Journal Article
Subjects: Nivolumab
case report
Appears in Collections:Journal articles

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