Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/23284
Title: Nivolumab resulting in persistently elevated troponin levels despite clinical remission of myocarditis and myositis in a patient with malignant pleural mesothelioma: case report.
Authors: Lie, Gabrielle;Weickhardt, Andrew;Kearney, Leighton G;Lam, Que;John, Thomas;Liew, David F L;Arulananda, Surein
Affiliation: Department of Cardiology, Austin Health, Heidelberg, Victoria, Australia
Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, Austin Health, Heidelberg, Victoria, Australia
Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia
Department of Pathology, Austin Health, Heidelberg, Victoria, Australia
Cancer Immuno-Biology Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
School of Cancer Medicine, La Trobe University, Heidelberg, Australia
Department of Rheumatology, Austin Health, Heidelberg, Victoria, Australia
Issue Date: Apr-2020
Citation: Translational lung cancer research 2020; 9(2): 360-365
Abstract: Malignant pleural mesothelioma (MPM) remains a deadly disease with limited therapeutic options beyond platinum/pemetrexed chemotherapy. Immune checkpoint inhibitors have demonstrated modest benefit in the second to later-line settings. An MPM patient from our institute developed myocarditis and myositis after 2 cycles of second-line nivolumab. Despite immunosuppression with corticosteroids and mycophenolate mofetil, there was ongoing rise in troponin levels which remained elevated for months. The patient developed an impressive but brief response following cessation of nivolumab. Myocarditis and myositis are rare complications of immune checkpoint inhibitors. Clinicians should be aware of these possible complications as myocarditis can result in mortality.
URI: http://ahro.austin.org.au/austinjspui/handle/1/23284
DOI: 10.21037/tlcr.2020.02.05
ORCID: 0000-0001-8451-8883
0000-0002-5636-6381
0000-0003-3399-5342
PubMed URL: 32420076
ISSN: 2218-6751
Type: Case Reports
Subjects: Nivolumab
case report
mesothelioma
myocarditis
myositis
Appears in Collections:Journal articles

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