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Title: | [¹⁸F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment. | Austin Authors: | Jeong, Hye Jin;Lee, Hyon;Lee, Sang Yoon;Seo, Seongho;Park, Kee Hyung;Lee, Yeong Bae;Shin, Dong Jin;Kang, Jae Myeong;Yeon, Byeong Kil;Kang, Seung Gul;Cho, Jaelim;Seong, Joon Kyung;Okamura, Nobuyuki;Villemagne, Victor L ;Na, Duk L;Noh, Young | Affiliation: | Department of Health Science and Technology, GAIHST, Gachon University, Incheon, Korea Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia Department of Neurology, Gachon University Gil Medical Center, Incheon, Korea Centre for PET, Austin Health, Heidelberg, Victoria, Australia Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Biomedical Engineering, Korea University, Seoul, Korea Department of Medicine, The University of Melbourne, Melbourne, VIC, Australia Department of Neuroscience, College of Medicine, Gachon University, Incheon, Korea Neuroscience Research Institute, Gachon University, Incheon, Korea Department of Occupational and Environmental Medicine, Gachon University Gil Medical Center, Incheon, Korea Department of Psychiatry, Gachon University Gil Medical Center, Incheon, Korea Department of Artificial Intelligence, Korea University, Seoul, Korea Samsung Alzheimer Research Center, Samsung Medical Center, Seoul, Korea Tohoku Medical and Pharmaceutical University, Sendai, Japan |
Issue Date: | Apr-2020 | Publication information: | Journal of clinical neurology (Seoul, Korea) 2020; 16(2): 202-214 | Abstract: | Mild cognitive impairment (MCI) is a condition with diverse clinical outcomes and subgroups. Here we investigated the topographic distribution of tau in vivo using the positron emission tomography (PET) tracer [¹⁸F]THK5351 in MCI subgroups. This study included 96 participants comprising 38 with amnestic MCI (aMCI), 21 with nonamnestic MCI (naMCI), and 37 with normal cognition (NC) who underwent 3.0-T MRI, [¹⁸F]THK5351 PET, and detailed neuropsychological tests. [¹⁸F]flutemetamol PET was also performed in 62 participants. The aMCI patients were further divided into three groups: 1) verbal-aMCI, only verbal memory impairment; 2) visual-aMCI, only visual memory impairment; and 3) both-aMCI, both visual and verbal memory impairment. Voxel-wise statistical analysis and region-of-interest -based analyses were performed to evaluate the retention of [¹⁸F]THK5351 in the MCI subgroups. Subgroup analysis of amyloid-positive and -negative MCI patients was also performed. Correlations between [¹⁸F]THK5351 retention and different neuropsychological tests were evaluated using statistical parametric mapping analyses. [¹⁸F]THK5351 retention in the lateral temporal, mesial temporal, parietal, frontal, posterior cingulate cortices and precuneus was significantly greater in aMCI patients than in NC subjects, whereas it did not differ significantly between naMCI and NC participants. [¹⁸F] THK5351 retention was greater in the both-aMCI group than in the verbal-aMCI and visualaMCI groups, and greater in amyloid-positive than amyloid-negative MCI patients. The cognitive function scores were significantly correlated with cortical [¹⁸F]THK5351 retention. [¹⁸F]THK5351 PET might be useful for identifying distinct topographic patterns of [¹⁸F]THK5351 retention in subgroups of MCI patients who are at greater risk of the progression to Alzheimer's dementia. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/23073 | DOI: | 10.3988/jcn.2020.16.2.202 | ORCID: | 0000-0003-3765-8546 0000-0002-0273-8960 0000-0002-6029-8553 0000-0001-7894-0535 0000-0001-6847-6679 0000-0001-5952-1423 0000-0002-4390-2843 0000-0003-0803-9332 0000-0002-4853-3178 0000-0003-4933-0433 0000-0002-4524-0310 0000-0001-6291-5415 0000-0002-5991-7812 0000-0002-5832-9875 0000-0003-1572-7862 0000-0002-9633-3314 |
Journal: | Journal of clinical neurology (Seoul, Korea) | PubMed URL: | 32319236 | ISSN: | 1738-6586 | Type: | Journal Article | Subjects: | mild cognitive impairment neurofibrillary tangles positron emission tomography |
Appears in Collections: | Journal articles |
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