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Title: A case of ANCA-associated vasculitis presenting de novo in pregnancy, successfully treated with rituximab.
Authors: Pefanis, Aspasia;Williams, David S;Skrzypek, H;Fung, A;Paizis, Kathy
Affiliation: Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia
Department of Obstetric, Medicine, Mercy Health, Melbourne, Australia
Issue Date: Mar-2020
EDate: 2018-07-26
Citation: Obstetric medicine 2020; 13(1): 41-44
Abstract: Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides are rare small vessel vasculitides of unknown cause. The pathogenic role of MPO-ANCA in the vasculitides has been supported using various animal models, with B-cells playing a role in the disease pathogenesis. Pregnancy in the presence of an autoimmune disease such as vasculitis is often associated with significant morbidity. Little is known about the outcomes when women present with de novo vasculitis during pregnancy, and the appropriate management of such presentations is unclear. We describe a case of a 33-year-old female presenting in her second pregnancy with new onset ANCA vasculitis at 12 weeks' gestation. She was successfully treated with prednisolone and rituximab, and delivered a healthy 2.8 kg boy at 36 weeks' gestation with no clinical manifestations of vasculitis or neutropenia in the neonate.
DOI: 10.1177/1753495X18780853
PubMed URL: 32284732
ISSN: 1753-495X
Type: Journal Article
Subjects: Antineutrophil cytoplasm antibody vasculitis
Appears in Collections:Journal articles

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