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Title: Incidence and risk factors for stroke following percutaneous coronary intervention.
Austin Authors: Dawson, Luke P;Cole, Justin A;Lancefield, Terase F;Ajani, Andrew E;Andrianopoulos, Nick;Thrift, Amanda G;Clark, David J ;Brennan, Angela L;Freeman, Melanie;O'Brien, Jessica;Sebastian, Martin;Chan, William;Shaw, James A;Dinh, Diem;Reid, Christopher M;Duffy, Stephen J
Affiliation: Stroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
School of Public Health, Curtin University, Perth, Australia
Department of Cardiology, University Hospital Geelong, Geelong, Australia
Department of Cardiology, Austin Health, Heidelberg, Victoria, Australia
Department of Cardiology, Box Hill Hospital, Melbourne, Australia
Department of Cardiovascular Medicine, The Alfred Hospital, Melbourne, Australia
Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia
Baker IDI Heart and Diabetes Institute, Melbourne, Australia
Issue Date: Oct-2020 2020-04-04
Publication information: International Journal of Stroke 2020; 15(8): 909-922
Abstract: Stroke rates and risk factors may change as percutaneous coronary intervention practice evolves and no data are available comparing stroke incidence after percutaneous coronary intervention to the general population. This study aimed to identify the incidence and risk factors for inpatient and subsequent stroke following percutaneous coronary intervention with comparison to age-matched controls. Data were prospectively collected from 22,618 patients undergoing percutaneous coronary intervention in the Melbourne Interventional Group registry (2005-2015). The cohort was compared to the North-East Melbourne Stroke Incidence Study population-based cohort (1997-1999) and predefined variables assessed for association with inpatient or outpatient stroke. Inpatient stroke occurred in 0.33% (65.3% ischemic, 28.0% haemorrhagic, and 6.7% cause unknown), while outpatient stroke occurred in 0.55%. Inpatient and outpatient stroke were associated with higher rates of in-hospital major adverse cardiovascular outcomes (p < 0.0001) and mortality (p < 0.0001), as well as 12-month mortality (p < 0.0001). Factors independently associated with inpatient stroke were renal impairment, ST-elevation myocardial infarction, previous stroke, left ventricular ejection fraction 30-45%, and female sex, while those associated with outpatient stroke were previous stroke, chronic lung disease, previous myocardial infarction, rheumatoid arthritis, female sex, and older age. Compared to the age-standardized population-based cohort, stroke rates in the 12 months following discharge were higher for percutaneous coronary intervention patients <65 years old, but lower for percutaneous coronary intervention patients ≥65 years old. Risk of inpatient stroke following percutaneous coronary intervention appears to be largely associated with clinical status at presentation, while outpatient stroke relates more to age and chronic disease. Compared to the general population, outpatient stroke rates following percutaneous coronary intervention are higher for younger, but not older, patients.
DOI: 10.1177/1747493020912607
ORCID: 0000-0003-3789-5808
Journal: International Journal of Stroke
PubMed URL: 32248767
Type: Journal Article
Subjects: Stroke
clinical outcomes
percutaneous coronary intervention
risk factors
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