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Title: Acute Kidney Injury and Postoperative Atrial Fibrillation In Patients Undergoing Cardiac Surgery.
Austin Authors: Cole, Oana M;Tosif, Shervin ;Shaw, Matthew;Lip, Gregory Y H
Affiliation: Liverpool Heart and Chest Hospital, Thomas Lane, Liverpool, United Kingdom
Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia
Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Issue Date: Jul-2020 2020-01-08
Publication information: Journal of Cardiothoracic and Vascular Anesthesia 2020; 34(7): 1783-1790
Abstract: To test the hypothesis that acute kidney injury (AKI) in the postoperative period could be an additional risk factor for the development of atrial fibrillation (AF) and to examine the risk factors for postoperative AF in the authors' cohort of patients. A retrospective observational study. Large regional cardiothoracic surgical center in the UK. Patients undergoing elective cardiac surgery at the authors' institution between July 1, 2013, and December 31, 2018. None. A total of 5,588 patients were included in the study. The incidence of postoperative AF was 1,384 (24.8%), and postoperative AKI occurred in 686 patients (12.3%). Postoperative AKI was significantly associated with postoperative AF after adjustment for preoperative variables (adjusted odds ratio = 1.572; 95% confidence interval = 1.295-1.908; p < 0.001). Other factors associated with postoperative AF were increasing age; increasing body mass index; New York Heart Association class ≥III; previous congestive heart failure; and recent myocardial infarction, coronary artery bypass graft with valve surgery, and aortic surgery (all p < 0.05). This analysis of a large, contemporary cohort of patients identifies postoperative AKI as an associated risk factor for postoperative AF, along with other perioperative variables. Early identification of this patient cohort would allow targeted preventative treatment to reduce the incidence of postoperative AF.
DOI: 10.1053/j.jvca.2019.12.048
PubMed URL: 32224024
Type: Journal Article
Subjects: acute kidney injury
cardiac surgery
postoperative atrial fibrillation
Appears in Collections:Journal articles

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