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Title: Risk factors for pregnancy outcomes in type 1 and type 2 diabetes.
Austin Authors: Seah, Jas-Mine ;Kam, Ning Mao;Wong, Lydia;Tanner, Cara ;Shub, Alexis;Ekinci, Elif I ;Houlihan, Christine
Affiliation: Department of Medicine Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Perinatal Medicine Mercy Health, Heidelberg, Victoria, Australia
Department of Endocrinology Austin Health, Heidelberg, Victoria, Australia
Issue Date: 1-Apr-2020 2020-04-01
Publication information: Internal Medicine Journal 2020; online first: 1 April
Abstract: Our aim was to explore differences in pregnancy outcomes between women with type 1 and type 2 diabetes, and healthy controls, and to examine the relationships between potential adverse risk factors and pregnancy outcomes in this cohort of women. This is a 10 year retrospective study of women with type 1 diabetes (n = 92), type 2 diabetes (n = 106) and healthy women without diabetes (controls) (n = 119) from a tertiary obstetric centre. Clinical and biochemical characteristics of women with type 1 and type 2 diabetes were determined and related to major obstetric outcomes using univariate analysis. Women with pre-existing diabetes had higher adverse pregnancy outcomes (preeclampsia, emergency caesarean section, preterm birth <32 and 37 weeks, large for gestational age, neonatal jaundice, Apgar score < 7 at 5 min, neonatal intensive care admission and neonatal hypoglycaemia) compared to controls. A higher birth weight gestational centile (97.4% vs. 72.4%, P = 0.001) and large for gestational age rate (63.4% vs. 35.8%, P = 0.001) were observed in type 1 diabetes compared to type 2 diabetes. There were no differences in other outcomes between women with type 1 and 2 diabetes. In this exploratory study, risk factors for maternal adverse outcomes differ between type 1 and type 2 diabetes. Maternal and fetal adverse outcomes were higher in pregnancies affected by diabetes compared to healthy women but occurred with similar frequency in women with type 1 and type 2 diabetes. This article is protected by copyright. All rights reserved.
DOI: 10.1111/imj.14840
ORCID: 0000-0001-5528-3966
PubMed URL: 32237194
Type: Journal Article
Appears in Collections:Journal articles

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