Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22761
Title: Three-step two-pot automated production of NCA [18F]FDOPA with FlexLab module.
Austin Authors: Huang, Ya-Yao;Poniger, Stan ;Tsai, Chia-Ling;Tochon-Danguy, Henri J ;Ackermann, Uwe ;Yen, Ruoh-Fang
Affiliation: PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan.
iPHASE Technologies, 3 Cypress Ave, Glen Waverley, Victoria, 3150, Australia
PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan
Molecular Imaging Center, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan
Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia
PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan
Issue Date: 22-Aug-2019
metadata.dc.date: 2019-08-22
Publication information: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2019; online first: 22 August
Abstract: Automated three-step two-pot production of no-carrier-added (NCA) [18F]FDOPA was first implemented in the iPHASE FlexLab module. Decay-corrected radiochemical yield (RCY) of [18F]FDOPA synthesized by this method was 10~14% (n = 7) with a synthesis time of ~110 min [18F]FDOPA was obtained in > 95% of radiochemical purity with a molar activity of ~431 GBq/μmol. With the method successfully implementing on the commercial FlexLab module and its built-in step-by-step activity monitoring, further processes optimization would be achieved.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22761
DOI: 10.1016/j.apradiso.2019.108871
PubMed URL: 32113705
Type: Journal Article
Subjects: Automated production
PET imaging
[(18)F]FDOPA
iPHASE FlexLab module
Appears in Collections:Journal articles

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