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Title: Cognitive Behavioral Therapy for Antenatal Depression in a Pilot Randomized Controlled Trial and Effects on Neurobiological, Behavioral and Cognitive Outcomes in Offspring 3-7 Years Postpartum: A Perspective Article on Study Findings, Limitations and Future Aims.
Austin Authors: Bleker, Laura S;Milgrom, Jeannette ;Sexton-Oates, Alexandra;Parker, Donna;Roseboom, Tessa J;Gemmill, Alan W ;Holt, Christopher J;Saffery, Richard;Connelly, Alan;Burger, Huibert;de Rooij, Susanne R
Affiliation: Academic Medical Centre, Department of Psychiatry, Amsterdam UMC, Amsterdam, Netherlands
Academic Medical Centre, Department of Obstetrics and Gynecology, Amsterdam UMC, Amsterdam, Netherlands
Academic Medical Centre, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, Amsterdam, Netherlands
University Medical Center Groningen, Department of General Practice, University of Groningen, Groningen, Netherlands
Parent-Infant Research Institute (PIRI), Austin Health, Heidelberg, Victoria, Australia
Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia
Murdoch Children's Research Institute-Cancer and Disease Epigenetics, Royal Children's Hospital, Melbourne, Victoria, Australia
Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia
Academic Medical Centre, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, Amsterdam, Netherlands
Issue Date: 13-Feb-2020
Date: 2020-02-13
Publication information: Frontiers in psychiatry 2020; 11: 34
Abstract: In a previous pilot randomized controlled trial including 54 pregnant women with depression, maternal mood improved after Cognitive Behavioural Therapy (CBT) compared to treatment as usual (TAU), showing medium to large effect sizes. The effect persisted up to 9 months postpartum, with infant outcomes also showing medium to large effects favoring CBT in various child domains. This perspective article summarizes the results of a follow-up that was performed approximately 5 years later in the same cohort, assessing the effects of antenatal Cognitive Behavioural Therapy for depression and anxiety on child buccal cell DNA-methylation, brain morphology, behavior and cognition. Children from the CBT group had overall lower DNA-methylation compared to children from the TAU group. Mean DNA-methylation of all NR3C1 promoter-associated probes did not differ significantly between the CBT and TAU groups. Children from the CBT group had a thicker right lateral occipital cortex and lingual gyrus. In the CBT group, Voxel-Based-Morphometry analysis identified one cluster showing increased gray matter concentration in the right medial temporal lobe, and fixel-based analysis revealed reduced fiber-bundle-cross-section in the Fornix, the Optical Tract, and the Stria Terminalis. No differences were observed in full-scale IQ or Total Problems Score. When the total of hypotheses tests in this study was considered, differences in DNA-methylation and brain measurements were no longer significant. Our explorative findings suggest that antenatal depression treatment decreases overall child DNA-methylation, increases cortical thickness, and decreases white matter fiber-bundle cross-section in regions involved in cognitive function and the stress response. Nevertheless, larger studies are warranted to confirm our preliminary conclusion that CBT in pregnancy alters neurobiological outcomes in children. Clinical relevance remains unclear as we found no effects of antenatal CBT on child behavior or cognition (yet).
DOI: 10.3389/fpsyt.2020.00034
ORCID: 0000-0002-4082-4595
Journal: Frontiers in psychiatry
PubMed URL: 32116849
ISSN: 1664-0640
Type: Journal Article
Subjects: Cognitive Behavioural Therapy
Appears in Collections:Journal articles

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