Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/22664
Title: Where ferroptosis inhibitors and paraquat detoxification mechanisms intersect, exploring possible treatment strategies.
Authors: Rashidipour, Niloofar;Karami-Mohajeri, Somayyeh;Mandegary, Ali;Mohammadinejad, Reza;Wong, Anselm Y;Mohit, Melika;Salehi, Jafar;Ashrafizadeh, Milad;Najafi, Amir;Abiri, Ardavan
Affiliation: Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Centre for Integrated Critical Care, Department of Medicine and Radiology, Melbourne Medical School, University of Melbourne, Victoria, Australia
Department of Anesthesiology, Faculty of Allied Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Victorian Poisons Information Centre, Austin Health, Heidelberg, Victoria, Australia
Austin Toxicology Service, Austin Health, Heidelberg, Victoria, Australia
Department of Emergency Medicine, Austin Health, Heidelberg, Victoria, Australia
Department of Toxicology and Pharmacology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Victoria, Australia
Department of Laboratory Sciences, Sirjan Faculty of Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran
Department of Anesthesiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
Department of Medicinal Chemistry, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
Issue Date: 12-Feb-2020
EDate: 2020-02-12
Citation: Toxicology 2020; 433-434: 152407
Abstract: Paraquat (PQ) is a fast-acting and effective herbicide that is used throughout the world to eliminate weeds. Over the past years, PQ was considered one of the most popular poisoning substances for suicide, and PQ poisoning accounts for about one-third of suicides around the world. Poisoning with PQ may cause multiorgan failure, pulmonary fibrosis, and ultimately death. Exposure to PQ results in the accumulation of PQ in the lungs, causing severe damage and, eventually, fibrosis. Until now, no effective antidote has been found to treat poisoning with PQ. In general, the toxicity of PQ is due to the formation of high energy oxygen free radicals and the peroxidation of unsaturated lipids in the cell. Ferroptosis is the result of the loss of glutathione peroxidase 4 (GPX4) activity that transforms iron-dependent lipid hydroperoxides to lipid alcohols, which are inert in the biological environment. Impaired iron metabolism and lipid peroxidation are increasingly known as the driving agents of ferroptosis. The contribution of ferroptosis to the development of cell death during poisoning with PQ has not yet been addressed. There is growing evidence about the relationship between PQ poisoning and ferroptosis. This raises the possibility of using ferroptosis inhibitors for the treatment of PQ poisoning. In this hypothesis-driven review article, we elaborated how ferroptosis inhibitors might circumvent the toxicity induced by PQ and may be potentially useful for the treatment of PQ toxicity.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22664
DOI: 10.1016/j.tox.2020.152407
ORCID: 0000-0002-6817-7289
PubMed URL: 32061663
Type: Journal Article
Review
Subjects: Ferroptosis
Herbicide
PQ
Paraquat
Poisoning
ROS
Appears in Collections:Journal articles

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