Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/22605
Title: Australian consensus statements for the regulation, production and use of faecal microbiota transplantation in clinical practice.
Authors: Haifer, Craig;Kelly, Colleen R;Paramsothy, Sudarshan;Andresen, David;Papanicolas, Lito E;McKew, Genevieve L;Borody, Thomas J;Kamm, Michael;Costello, Samuel P;Andrews, Jane M;Begun, Jakob;Chan, Hiu Tat;Connor, Susan;Ghaly, Simon;Johnson, Paul DR;Lemberg, Daniel A;Paramsothy, Ramesh;Redmond, Andrew;Sheorey, Harsha;van der Poorten, David;Leong, Rupert W
Affiliation: Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
The University of Adelaide, Adelaide, South Australia, Australia
The University of Sydney, Sydney, New South Wales, Australia
Concord Repatriation General Hospital, Sydney, New South Wales, Australia
The University of Queensland, Brisbane, Queensland, Australia
Mater Hospital Brisbane, Brisbane, Queensland, Australia
Liverpool Hospital, Sydney, New South Wales, Australia
University of New South Wales, Sydney, New South Wales, Australia
Austin Health, Heidelberg, Victoria, Australia
Sydney Children's Hospital Randwick, Randwick, New South Wales, Australia
Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia
Westmead Hospital, Sydney, New South Wales, Australia
Blacktown Hospital, Sydney, New South Wales, Australia
VCS Pathology, Melbourne, Victoria, Australia
Centre for Digestive Diseases, Sydney, New South Wales, Australia
St Vincent's Hospital, Melbourne, Victoria, Australia
The University of Sydney, Sydney, New South Wales, Australia
St Vincent's Hospital, Sydney, New South Wales, Australia
Concord Repatriation General Hospital, Sydney, New South Wales, Australia
South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia
Royal Adelaide Hospital, Adelaide, South Australia, Australia
The University of Melbourne, Melbourne, Victoria, Australia
The Queen Elizabeth Hospital, Woodville, South Australia, Australia
BiomeBank, Adelaide, South Australia, Australia
Issue Date: 11-Feb-2020
EDate: 2020-02-11
Citation: Gut 2020; online first: 11 February
Abstract: Faecal microbiota transplantation (FMT) has proved to be an extremely effective treatment for recurrent Clostridioides difficile infection, and there is interest in its potential application in other gastrointestinal and systemic diseases. However, the recent death and episode of septicaemia following FMT highlights the need for further appraisal and guidelines on donor evaluation, production standards, treatment facilities and acceptable clinical indications. For these consensus statements, a 24-member multidisciplinary working group voted online and then convened in-person, using a modified Delphi approach to formulate and refine a series of recommendations based on best evidence and expert opinion. Invitations to participate were directed to Australian experts, with an international delegate assisting the development. The following issues regarding the use of FMT in clinical practice were addressed: donor selection and screening, clinical indications, requirements of FMT centres and future directions. Evidence was rated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. Consensus was reached on 27 statements to provide guidance on best practice in FMT. These include: (1) minimum standards for donor screening with recommended clinical selection criteria, blood and stool testing; (2) accepted routes of administration; (3) clinical indications; (4) minimum standards for FMT production and requirements for treatment facilities acknowledging distinction between single-site centres (eg, hospital-based) and stool banks; and (5) recommendations on future research and product development. These FMT consensus statements provide comprehensive recommendations around the production and use of FMT in clinical practice with relevance to clinicians, researchers and policy makers.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22605
DOI: 10.1136/gutjnl-2019-320260
ORCID: 0000-0002-3675-6550
0000-0002-9097-6028
0000-0002-5838-7274
0000-0002-5238-9260
0000-0002-0519-4698
0000-0002-2857-1812
0000-0001-5256-7672
0000-0001-5606-0270
0000-0003-2489-6430
0000-0002-1125-5362
0000-0001-5944-3488
0000-0001-9873-7163
PubMed URL: 32047093
Type: Journal Article
Subjects: Clostridioides difficile
FMT
faecal microbiota transplantation
inflammatory bowel disease
microbiome therapeutics
stool bank
Appears in Collections:Journal articles

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