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Title: PSMA-PET guided hook-wire localization of nodal metastases in prostate cancer: a targeted approach.
Austin Authors: Clarebrough, Emma;Duncan, Catriona;Christidis, Daniel;Lavoipierre, Alain;Lawrentschuk, Nathan
Affiliation: Department of Surgery, Royal Melbourne Hospital, Parkville, Melbourne, VIC, Australia
Department of Surgery, University of Melbourne, Melbourne, VIC, Australia
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia
Epworth Medical Imagig, Epworth Freemasons Hospital Melbourne, Melbourne, VIC, Australia
Young Urology Research Organisation (YURO), Melbourne, Australia
Department of Urology, Austin Health, Heidelberg, Victoria, Australia
Issue Date: Jul-2019 2018-04-03
Publication information: World Journal of Urology 2019; 37(7): 1251-1254
Abstract: Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (PSMA-PET/CT) has increased the sensitivity and specificity of imaging to identify metastatic prostate cancer in the group of patients with early biochemical recurrence when compared to conventional imaging. In patients who develop biochemical recurrence of prostate cancer following surgical resection, salvage lymph node dissection may reduce prostate specific antigen (PSA) levels and delay the time for commencement of systemic therapies. However, PLND may be an anatomically and technically difficult procedure, particularly with small metastatic diseases which can be problematic for intra-operative identification. We describe the technique using PSMA-PET imaging to pre-operatively localise areas of low-volume nodal metastatic disease with hookwire to allow targeted lymph node dissection with direct visualisation and palpation to ensure adequate clearance of involved nodes.
DOI: 10.1007/s00345-018-2282-y
ORCID: 0000-0002-6321-4618
PubMed URL: 29616296
Type: Journal Article
Subjects: Hookwire
Image guided surgery
Lymph node metastasis
Pelvic lymph node dissection
Prostate cancer
Appears in Collections:Journal articles

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