Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22455
Title: Levetiracetam efficacy in PCDH19 Girls Clustering Epilepsy.
Austin Authors: Sadleir, Lynette G;Kolc, Kristy L;King, Chontelle;Mefford, Heather C;Dale, Russell C;Gecz, Jozef;Scheffer, Ingrid E 
Affiliation: Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand
Department of Pediatrics, Division of Genetic Medicine, University of Washington, Seattle, WA, 98195, USA
The Florey Institute and Murdoch Children's Research Institute, Melbourne, VIC, Australia
Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand
Adelaide Medical School, The University of Adelaide, SA, Australia
Robinson Research Institute, The University of Adelaide, SA, Australia
Healthy Mothers and Babies, South Australian Health and Medical Research Institute, SA, Australia
Kids Neuroscience Centre. Children's Hospital at Westmead, University of Sydney, Australia
Epilepsy Research Centre, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Paediatrics, Royal Children's Hospital, The University of Melbourne, VIC, Australia
Issue Date: Jan-2020
metadata.dc.date: 2020-01-03
Publication information: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2020; 24: 142-147
Abstract: PCDH19 Girls clustering epilepsy (GCE) has a phenotypic spectrum that includes developmental and epileptic encephalopathy. PCDH19-GCE presents with clusters of seizures in the first years of life. Although patients typically outgrow their seizures, many are left with intellectual disability. Here we retrospectively assess the effect of levetiracetam in two independent cohorts of females with PCDH19-GCE. Cohort A was identified by searching our epilepsy genetics research database for girls with PCDH19-GCE who had trialled levetiracetam. Cohort B consisted of girls aged 2 years or older, including women, participating in an international online questionnaire. Information regarding seizure frequency and levetiracetam use was obtained by in-person patient interview and review of clinical records for cohort A, and by patient report for cohort B. Cohort A consisted of 17 females, aged 3-37 years, who had a trial of levetiracetam at an average age of 10.7 years. 13/17 females became seizure free for >12 months; while 10/17 remained seizure free for >24 months. Cohort B comprised 62 females, aged 1.5-41 years. 26/62 became seizure free for >12 months, and 19/62 for >24 months on levetiracetam therapy. Levetiracetam was effective in two cohorts of females with PCDH19-GCE where 42% and 76% of females became seizure free for >12 months, respectively. Levetiracetam is an effective therapy for females with PCDH19-GCE and should be considered early in the management of the highly refractory clusters of seizures that characterise this genetic disease.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22455
DOI: 10.1016/j.ejpn.2019.12.020
ORCID: 0000-0002-2311-2174
PubMed URL: 31928905
Type: Journal Article
Subjects: Anti-epileptic drug
Developmental and epileptic encephalopathy
Epilepsy
Genetic
Levetiracetam
PCDH19
Appears in Collections:Journal articles

Show full item record

Page view(s)

10
checked on Dec 8, 2022

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.