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https://ahro.austin.org.au/austinjspui/handle/1/22410| Title: | Using genomics to understand meticillin- and vancomycin-resistant Staphylococcus aureus infections. | Austin Authors: | Giulieri, Stefano G ;Tong, Steven Y C;Williamson, Deborah A | Affiliation: | Victorian Infectious Disease Service, Royal Melbourne Hospital, and Doherty Department University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, Australia Microbiological Diagnostic Unit Public Health Laboratory, University of Melbourne at the Peter Doherty Institute of Infection and Immunity, Melbourne, Australia Menzies School of Health Research, Darwin, Australia Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia Microbiology, Royal Melbourne Hospital, Melbourne, Australia |
Issue Date: | 8-Jan-2020 | Date: | 2020-01-08 | Publication information: | Microbial genomics 2020; 6(1): e000324 | Abstract: | Resistance to meticillin and vancomycin in Staphylococcus aureus significantly complicates the management of severe infections like bacteraemia, endocarditis or osteomyelitis. Here, we review the molecular mechanisms and genomic epidemiology of resistance to these agents, with a focus on how genomics has provided insights into the emergence and evolution of major meticillin-resistant S. aureus clones. We also provide insights on the use of bacterial whole-genome sequencing to inform management of S. aureus infections and for control of transmission at the hospital and in the community. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/22410 | DOI: | 10.1099/mgen.0.000324 | Journal: | Microbial genomics | PubMed URL: | 31913111 | Type: | Journal Article | Subjects: | MRSA Staphylococcus aureus antibiotic resistance genomics vancomycin |
| Appears in Collections: | Journal articles |
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