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Title: Using genomics to understand meticillin- and vancomycin-resistant Staphylococcus aureus infections.
Authors: Giulieri, Stefano G;Tong, Steven Y C;Williamson, Deborah A
Affiliation: Victorian Infectious Disease Service, Royal Melbourne Hospital, and Doherty Department University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, Australia
Microbiological Diagnostic Unit Public Health Laboratory, University of Melbourne at the Peter Doherty Institute of Infection and Immunity, Melbourne, Australia
Menzies School of Health Research, Darwin, Australia
Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia
Microbiology, Royal Melbourne Hospital, Melbourne, Australia
Issue Date: 8-Jan-2020
EDate: 2020-01-08
Citation: Microbial genomics 2020; online first: 8 January
Abstract: Resistance to meticillin and vancomycin in Staphylococcus aureus significantly complicates the management of severe infections like bacteraemia, endocarditis or osteomyelitis. Here, we review the molecular mechanisms and genomic epidemiology of resistance to these agents, with a focus on how genomics has provided insights into the emergence and evolution of major meticillin-resistant S. aureus clones. We also provide insights on the use of bacterial whole-genome sequencing to inform management of S. aureus infections and for control of transmission at the hospital and in the community.
DOI: 10.1099/mgen.0.000324
PubMed URL: 31913111
Type: Journal Article
Subjects: MRSA
Staphylococcus aureus
antibiotic resistance
Appears in Collections:Journal articles

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