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https://ahro.austin.org.au/austinjspui/handle/1/22405| Title: | Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells. | Austin Authors: | Rigau, Marc;Ostrouska, Simone;Fulford, Thomas S;Johnson, Darryl N;Woods, Katherine;Ruan, Zheng;McWilliam, Hamish E G;Hudson, Christopher;Tutuka, Candani;Wheatley, Adam K;Kent, Stephen J;Villadangos, Jose A;Pal, Bhupinder;Kurts, Christian;Simmonds, Jason;Pelzing, Matthias;Nash, Andrew D;Hammet, Andrew;Verhagen, Anne M;Vairo, Gino;Maraskovsky, Eugene;Panousis, Con;Gherardin, Nicholas A;Cebon, Jonathan S ;Godfrey, Dale I;Behren, Andreas;Uldrich, Adam P | Affiliation: | University of Bonn, Bonn, Germany Department of Microbiology & Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria 3010, Australia Ludwig Institute for Cancer Research, Melbourne -Austin Branch Victoria 3084, Australia Australian Research Council Centre of Excellence for Advanced Molecular Imaging at the University of Melbourne, Victoria 3010, Australia Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia School of Cancer Medicine, La Trobe University, Heidelberg, Victoria 3084, Australia Department of Biochemistry and Molecular Biology at the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia Australian Research Council Centre of Excellence for Convergent Bio-Nano Science and Technology at the University of Melbourne, Victoria 3010, Australia Department of Medicine, The University of Melbourne, Melbourne, Victoria 3010, Australia CSL Limited at the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia University of Bonn, Bonn, Germany |
Issue Date: | 7-Feb-2020 | Date: | 2020-01-09 | Publication information: | Science 2020; 367(6478): eaay5516 | Abstract: | Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) that respond to phosphoantigens (pAg) produced by cellular pathogens and overexpressed by cancers. However, the molecular targets recognized by these γδTCRs are unknown. Here, we identify butyrophilin 2A1 (BTN2A1) as a key ligand that binds to the Vγ9+ TCR γ-chain. BTN2A1 associates with another butyrophilin, BTN3A1, which act together to initiate responses to pAg. Furthermore, binding of a second ligand, possibly BTN3A1, to a separate TCR domain incorporating Vδ2 is also required. This unique mode of Ag-dependent T cell activation advances our understanding of diseases involving pAg recognition and creates opportunities for the development of γδ T cell-based immunotherapies. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/22405 | DOI: | 10.1126/science.aay5516 | ORCID: | 0000-0001-5978-1073 0000-0001-7582-3990 0000-0003-3474-3104 0000-0003-3479-3419 0000-0002-1420-6988 0000-0003-3344-4102 0000-0002-5593-9387 0000-0002-8539-4891 0000-0001-6771-8891 0000-0002-6620-2401 0000-0003-1947-8701 0000-0003-1330-7303 0000-0002-6945-8672 0000-0003-3690-6253 0000-0003-4690-2571 0000-0002-3898-950X 0000-0002-3009-5472 0000-0001-5329-280X 0000-0002-6350-5976 |
Journal: | Science | PubMed URL: | 31919129 | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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