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Title: Beware Ketoacidosis with SGLT2 Inhibitors in Latent Autoimmune Diabetes of the Adult.
Austin Authors: Nolan, Brendan James ;Varadarajan, Suresh;Fourlanos, Spiros;Neoh, Sandra L 
Affiliation: Endocrinology
Department of Diabetes and Endocrinology, The Royal Melbourne Hospital, Parkville, Victoria, Australia
Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia
Department of Endocrinology, Northern Hospital, Epping, Victoria, Australia
Issue Date: Aug-2020
Date: 2020-01-07
Publication information: The American Journal of Medicine 2020; 133(8): e422-e424
Abstract: Sodium-glucose co-transporter-2 (SGLT2) inhibitors are increasingly used for the treatment of type 2 diabetes but have been associated with ketoacidosis. We report a case series of three patients with latent autoimmune diabetes who presented with ketoacidosis, including one case with normal blood glucose levels, in the context of SGLT2 inhibitor use. SGLT2 inhibitors should only be used with caution and close clinical monitoring in patients with latent autoimmune diabetes. A clinical risk score permits targeted autoantibody testing and should be undertaken prior to commencement of SGLT2 inhibitors and/or cessation of insulin.
DOI: 10.1016/j.amjmed.2019.12.006
Journal: The American Journal of Medicine
PubMed URL: 31923401
Type: Journal Article
Subjects: SGLT2 inhibitor
diabetic ketoacidosis
latent autoimmune diabetes
Appears in Collections:Journal articles

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