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Title
Beware Ketoacidosis with SGLT2 Inhibitors in Latent Autoimmune Diabetes of the Adult.
Publication Date
2020-08
Author(s)
Nolan, Brendan James
Varadarajan, Suresh
Fourlanos, Spiros
Neoh, Sandra L
Subject
SGLT2 inhibitor
diabetes
diabetic ketoacidosis
latent autoimmune diabetes
Type of document
Journal Article
OrcId
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DOI
10.1016/j.amjmed.2019.12.006
Abstract
Sodium-glucose co-transporter-2 (SGLT2) inhibitors are increasingly used for the treatment of type 2 diabetes but have been associated with ketoacidosis. We report a case series of three patients with latent autoimmune diabetes who presented with ketoacidosis, including one case with normal blood glucose levels, in the context of SGLT2 inhibitor use. SGLT2 inhibitors should only be used with caution and close clinical monitoring in patients with latent autoimmune diabetes. A clinical risk score permits targeted autoantibody testing and should be undertaken prior to commencement of SGLT2 inhibitors and/or cessation of insulin.
Link
Citation
The American Journal of Medicine 2020; 133(8): e422-e424
Jornal Title
The American Journal of Medicine

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