Please use this identifier to cite or link to this item:
Title: A Review of Key Biological and Molecular Events Underpinning Transformation of Melanocytes to Primary and Metastatic Melanoma.
Austin Authors: Jackett, Louise A ;Scolyer, Richard A
Affiliation: Department of Anatomical Pathology, Austin Health, Heidelberg, Victoria, Australia
Melanoma Institute Australia, 2065 Sydney, Australia
Sydney Medical School, The University of Sydney, 2050 Sydney, Australia
Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, 2050 Sydney, Australia
Issue Date: 17-Dec-2019 2019
Publication information: Cancers 2019; 11(12)
Abstract: Melanoma is a major public health concern that is responsible for significant morbidity and mortality, particularly in countries such as New Zealand and Australia where it is the commonest cause of cancer death in young adults. Until recently, there were no effective drug therapies for patients with advanced melanoma however significant advances in our understanding of the biological and molecular basis of melanoma in recent decades have led to the development of revolutionary treatments, including targeted molecular therapy and immunotherapy. This review summarizes our current understanding of the key events in the pathway of melanomagenesis and discusses the role of genomic analysis as a potential tool for improved diagnostic evaluation, prognostication and treatment strategies. Ultimately, it is hoped that a continued deeper understanding of the mechanisms of melanomagenesis will lead to the development of even more effective treatments that continue to provide better outcomes for patients with melanoma.
DOI: 10.3390/cancers11122041
ORCID: 0000-0003-2792-6199
PubMed URL: 31861163
ISSN: 2072-6694
Type: Journal Article
Subjects: diagnosis
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Nov 25, 2022

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.