Please use this identifier to cite or link to this item:
Title: Hepatitis B virus activity is not associated with degree of liver steatosis in patients with Hepatitis B-related chronic liver disease.
Austin Authors: Worland, Thomas ;Apostolov, Ross ;Asadi, Khashayar ;Leung, Christopher 
Affiliation: Gastroenterology and Hepatology
Issue Date: Jun-2020
Date: 2019-12-28
Publication information: Liver International 2020; 40(6): 1500-1502
Abstract: The recently published manuscript by Zhu and colleagues "Hepatitis B virus infection and risk of non-alcoholic fatty liver disease: A population-based cohort study" found no correlation between presence of chronic HBV and presence of common risk factors for non-alcoholic fatty liver disease on primary analysis. A limitation to this study, like most population based research, is the absence of liver histology, which is considered gold standard for assessment of non-alcoholic fatty liver disease. Our group studied the association between hepatitis B viral activity and non-alcoholic fatty liver disease activity as measured by grade of steatohepatitis/fibrosis on liver biopsy by analysing consecutive liver histology samples from patients with chronic hepatitis B at a single quaternary liver transplant centre. Linear regression modelling for active viral hepatitis on histologic examination against degree of steatohepatitis showed no correlation (r2 0.018, all P>0.1). Linear regression of degree of steatohepatitis versus hepatitis B viral load also showed no correlation. Our work is concordant with the manuscript from Zhu et al; we found no significant correlation between hepatitis B viral activity and degree of steatohepatitis.
DOI: 10.1111/liv.14344
ORCID: 0000-0001-5122-5750
Journal: Liver International
PubMed URL: 31883410
Type: Journal Article
Subjects: Hepatitis B
Non-alcoholic fatty liver disease
fatty liver
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Jul 20, 2024

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.