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Title: Effect of salt supplementation on sympathetic activity and endothelial function in salt sensitive type 2 diabetes.
Austin Authors: Baqar, Sara;Kong, Yee Wen;Chen, Angela X;O'Callaghan, Christopher J ;Macisaac, Richard J;Bouterakos, Maree;Lambert, Gavin W;Jerums, George ;Lambert, Elisabeth E;Ekinci, Elif I 
Affiliation: Endocrinology
General Medicine
Department of Endocrinology & Diabetes, St Vincent's Hospital, Melbourne, Australia
Department of Medicine, The University of Melbourne, Victoria, Australia
Clinical Pharmacology and Therapeutics
Human Neurotransmitters Laboratory, Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia
Iverson Health Innovation Research Institute and Faculty of Health, Arts and Design, Swinburne University of Technology, Victoria, Australia
Issue Date: 1-Apr-2020
Date: 2019-11-25
Publication information: The Journal of Clinical Endocrinology and Metabolism 2020; 105(4): dgz219
Abstract: To determine if sympathetic nervous system (SNS) activation and endothelial dysfunction contribute to these observations, we examined the effect of salt supplementation on these systems in people with T2D with habitual low sodium. We hypothesized that salt supplementation will lower SNS activity and improve endothelial function compared to placebo. Randomized, double blinded, placebo-controlled, cross-over trial. Tertiary referral diabetes outpatients clinic. Salt supplementation (100mmol NaCl/24h) or placebo for three weeks was administered. Compared to placebo, salt supplementation increased MSNA (burst frequency p= 0.047, burst incidence p=0.016) however RHI (p=0.24), AI (p=0.201), ABPM (systolic p=0.09, diastolic p=0.14) and HRV were unaffected. Salt supplementation improved baroreflex (slope p=0.026), lowered aldosterone (p=0.004) and in salt-resistant individuals there was a trend towards improved RHI (p=0.07). In people with T2D and low habitual sodium intake, salt supplementation increased SNS activity without altering endothelial function or blood pressure but improved baroreflex function, a predictor of cardiac mortality. Salt-resistant individuals trended towards improved endothelial function with salt supplementation.
DOI: 10.1210/clinem/dgz219
ORCID: 0000-0002-4921-1349
Journal: The Journal of Clinical Endocrinology and Metabolism
PubMed URL: 31761946
Type: Journal Article
Subjects: endothelial dysfunction
renin-angiotensin-aldosterone system
salt sensitivity
sympathetic nervous system
twenty-four-hour urinary sodium excretion
type two diabetes
Appears in Collections:Journal articles

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