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Title: Bone Marrow Adipose Tissue Quantification by Imaging.
Austin Authors: Bani Hassan, Ebrahim;Ghasem-Zadeh, Ali ;Imani, Mahdi;Kutaiba, Numan ;Wright, David K;Sepehrizadeh, Tara;Duque, Gustavo
Affiliation: Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, Victoria, Australia
Department of Medicine-Western Health, The University of Melbourne, St. Albans, Victoria, Australia
Medicine (University of Melbourne)
Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia
Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia
Issue Date: Dec-2019
Date: 2019-11-11
Publication information: Current Osteoporosis Reports 2019; 17(6): 416-428
Abstract: The significance and roles of marrow adipose tissue (MAT) are increasingly known, and it is no more considered a passive fat storage but a tissue with significant paracrine and endocrine activities that can cause lipotoxicity and inflammation. Changes in the MAT volume and fatty acid composition appear to drive bone and hematopoietic marrow deterioration, and studying it may open new horizons to predict bone fragility and anemia development. MAT has the potential to negatively impact bone volume and strength through several mechanisms that are partially described by┬áinflammaging and lipotoxicity terminology. Evidence indicates paramount importance of MAT in age-associated decline of bone and red marrow structure and function. Currently, MAT measurement is being tested and validated by several techniques. However, purpose-specific adaptation of existing imaging technologies and, more importantly, development of new modalities to quantitatively measure MAT are yet to be done.
DOI: 10.1007/s11914-019-00539-5
Journal: Current Osteoporosis Reports
PubMed URL: 31713178
Type: Journal Article
Subjects: CT
Hematopoietic marrow
Red marrow
Yellow marrow
Appears in Collections:Journal articles

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