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Title: Letter to the editor: Elevated Plasma Levels of Cell-Free DNA During Liver Transplantation Are Associated With Activation of Coagulation.
Austin Authors: Yoshino, Osamu ;Muralidharan, Vijayaragavan ;Dobrovic, Alexander ;Goh, Su Kah 
Affiliation: Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Translational Genomics & Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
Issue Date: Apr-2020 2019-11-29
Publication information: Livert Transplantation 2020; 26(4): 602-603
Abstract: Cell-free DNA (cfDNA) is emerging as an immuno-modulator in numerous medical conditions including in malignancy, chronic inflammatory diseases, trauma, sepsis, and organ transplantation. Significant evidence exists supporting a link between cfDNA and the presence of neutrophil extracellular traps (NETs). NETs, comprising an extra-cellular mesh of chromatin and neutrophil granular proteins, enable extracellular pathogen entrapment and clearance. NETs have attracted attention as they play a critical role in the immune system. Furthermore, Early reports have demonstrated that the inhibition of NETs can modulate the immune response .
DOI: 10.1002/lt.25695
ORCID: 0000-0002-6684-2521
PubMed URL: 31782969
Type: Journal Article
Appears in Collections:Journal articles

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