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Cell-free DNA (cfDNA) is emerging as an immuno-modulator in numerous medical conditions including in malignancy, chronic inflammatory diseases, trauma, sepsis, and organ transplantation. Significant evidence exists supporting a link between cfDNA and the presence of neutrophil extracellular traps (NETs). NETs, comprising an extra-cellular mesh of chromatin and neutrophil granular proteins, enable extracellular pathogen entrapment and clearance. NETs have attracted attention as they play a critical role in the immune system. Furthermore, Early reports have demonstrated that the inhibition of NETs can modulate the immune response . |
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