Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22014
Title: Childhood pneumonia, pleurisy and lung function: a cohort study from the first to sixth decade of life.
Austin Authors: Perret, Jennifer L ;Lodge, Caroline J;Lowe, Adrian J;Johns, David P;Thompson, Bruce R;Bui, Dinh S;Gurrin, Lyle C;Matheson, Melanie C;McDonald, Christine F ;Wood-Baker, Richard;Svanes, Cecilie;Thomas, Paul S;Giles, Graham G;Chang, Anne B;Abramson, Michael J;Walters, E Haydn;Dharmage, Shyamali C
Affiliation: Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway
Department of Medicine, Monash University, Melbourne, Victoria, Australia
Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia
Centre for International Health, University of Bergen, Bergen, Norway
Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia
NHMRC Centre of Research Excellence for Chronic Respiratory Disease‎, University of Tasmania, Hobart, Tasmania, Australia
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Child Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia
Department of Respiratory Medicine, Queensland Children's Hospital, Brisbane, Queensland, Australia
Queensland University of Technology, Brisbane, Queensland, Australia
Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia
Prince of Wales' Hospital Clinical School and School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia
Institute for Breathing and Sleep (IBAS), Melbourne, Victoria, Australia
Department of Respiratory Medicine, The Alfred Hospital, Melbourne, Victoria, Australia
Issue Date: 30-Oct-2019
metadata.dc.date: 2019-10-30
Publication information: Thorax 2020; 75(1): 28-37
Abstract: Adult spirometry following community-acquired childhood pneumonia has variably been reported as showing obstructive or non-obstructive deficits. We analysed associations between doctor-diagnosed childhood pneumonia/pleurisy and more comprehensive lung function in a middle-aged general population cohort born in 1961. Data were from the prospective population-based Tasmanian Longitudinal Health Study cohort. Analysed lung function was from ages 7 years (prebronchodilator spirometry only, n=7097), 45 years (postbronchodilator spirometry, carbon monoxide transfer factor and static lung volumes, n=1220) and 53 years (postbronchodilator spirometry and transfer factor, n=2485). Parent-recalled histories of doctor-diagnosed childhood pneumonia and/or pleurisy were recorded at age 7. Multivariable linear and logistic regression were used. At age 7, compared with no episodes, childhood pneumonia/pleurisy-ever was associated with reduced FEV1:FVC for only those with current asthma (beta-coefficient or change in z-score=-0.20 SD, 95% CI -0.38 to -0.02, p=0.028, p interaction=0.036). At age 45, for all participants, childhood pneumonia/pleurisy-ever was associated with a restrictive pattern: OR 3.02 (1.5 to 6.0), p=0.002 for spirometric restriction (FVC less than the lower limit of normal plus FEV1:FVC greater than the lower limit of normal); total lung capacity z-score -0.26 SD (95% CI -0.38 to -0.13), p<0.001; functional residual capacity -0.16 SD (-0.34 to -0.08), p=0.001; and residual volume -0.18 SD (-0.31 to -0.05), p=0.008. Reduced lung volumes were accompanied by increased carbon monoxide transfer coefficient at both time points (z-score +0.29 SD (0.11 to 0.49), p=0.001 and +0.17 SD (0.04 to 0.29), p=0.008, respectively). For this community-based population, doctor-diagnosed childhood pneumonia and/or pleurisy were associated with obstructed lung function at age 7 for children who had current asthma symptoms, but with evidence of 'smaller lungs' when in middle age.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22014
DOI: 10.1136/thoraxjnl-2019-213389
ORCID: 0000-0001-7034-0615
0000-0001-6481-3391
PubMed URL: 31666389
Type: Journal Article
Subjects: clinical epidemiology
respiratory infection
Appears in Collections:Journal articles

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