Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/21956
Title: Hydrocortisone Compared with Placebo in Patients with Septic Shock Satisfying the Sepsis-3 Diagnostic Criteria and APROCCHSS Study Inclusion Criteria: A Post Hoc Analysis of the ADRENAL Trial.
Austin Authors: Venkatesh, Balasubramanian;Finfer, Simon;Cohen, Jeremy;Rajbhandari, Dorrilyn;Arabi, Yaseen;Bellomo, Rinaldo ;Billot, Laurent;Glass, Parisa;Joyce, Christopher;Li, Qiang;McArthur, Colin;Perner, Anders;Rhodes, Andrew;Thompson, Kelly;Webb, Steve;Myburgh, John
Affiliation: St. George Hospital, University of New South Wales, Sydney, New South Wales
Royal Perth Hospital, Perth, Western Australia, Australia
University of Western Australia, School of Medicine and Pharmacology, Perth, Western Australia
George Institute for Global Health, Sydney, New South Wales, Australia
Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia
Wesley Hospital, Brisbane, Queensland, Australia
University of New South Wales, Sydney, New South Wales, Australia
Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
Royal North Shore Hospital, Sydney, New South Wales, Australia
Royal Brisbane and Women's Hospital, University of Queensland, Brisbane, Queensland, Australia
King Abdulaziz Medical City, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Austin Health, Heidelberg, Victoria, Australia
the Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand
Rigshospitalet, Copenhagen, Denmark
St. George's Hospital, London, United Kingdom
Issue Date: Dec-2019
metadata.dc.date: 2019-10-16
Publication information: Anesthesiology 2019; 13(6): 1292-1300
Abstract: Definitions and management strategies for septic shock continue to be updated as defined in Sepsis-2, Sepsis-3, and other guidelinesRecent randomized controlled trials of corticosteroids in septic shock report different treatment effects on 90-day mortality but use different inclusion criteria WHAT THIS ARTICLE TELLS US THAT IS NEW: In a post hoc analysis of the Adjunctive Glucocorticoid Therapy in Patients with Septic Shock (ADRENAL) trial, in participants who fulfilled either the Sepsis-3 or -2 inclusion criteria or those with severe septic shock, a continuous infusion of hydrocortisone did not result in a lower 90-day mortality than placebo BACKGROUND
URI: http://ahro.austin.org.au/austinjspui/handle/1/21956
DOI: 10.1097/ALN.0000000000002955
ORCID: 0000-0002-1650-8939
PubMed URL: 31651531
Type: Journal Article
Appears in Collections:Journal articles

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