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Title: Is There an Optimal Curative Option in HIV-Positive Men with Localized Prostate Cancer? A Systematic Review.
Austin Authors: Baladakis, John;Perera, Marlon ;Bolton, Damien M ;Lawrentschuk, Nathan;Adam, Ahmed
Affiliation: Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Surgery, University of Queensland, Brisbane, QLD
Olivia-Newton John Cancer Centre, University of Melbourne, Melbourne, VIC
Department of Urology, Helen Joseph Hospital, University of the Witwatersrand, Johannesburg, South Africa
Department of Pediatric Urology, Rahima Moosa Mother & Child (Coronation) Hospital, University of the Witwatersrand, Johannesburg, South Africa
Division of Urology, Department of Surgery, Faculty of Health Sciences, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa
Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia
Issue Date: Jul-2019
Date: 2019-07-20
Publication information: Current urology 2019; 12(4): 169-176
Abstract: We aimed to compare the outcome of curative treatment options in localised Prostate Cancer (PCa) amongst HIV positive (HIV+) men. A systematic search of the Cochrane Library of Systematic Reviews, the Scopus and PubMed databases was performed (January 1995 to November 2015) using pre-determined search terms. Outcome measures for comparison included the rate of biochemical failure (BCF), survival benefit and complications. A total of 14 eligible articles were identified for inclusion, representing a total of 202 HIV+ men with PCa. Radical Prostatectomy was performed in 40/153 compared to 109/153 patients undergoing alternative (non-surgical) treatments options. Only 3 studies compared outcomes within their respective study cohort. One study (n = 10) reported BCF results with 1/2 BCF patient in the surgical arm vs. 1/8 BCF positive patients in the non-surgical arm (mean 46 months follow-up), while two other studies reported no occurrences of BCF within both arms of their studies. Due to paucity in the literature, there is insufficient evidence to support a certain treatment modality arm specifically for HIV+ men with localized PCa. An individualized management algorithm seems feasible within this cohort, until more definitive studies are performed.
DOI: 10.1159/000499309
ORCID: 0000-0002-1138-6389
Journal: Current urology
PubMed URL: 31602182
ISSN: 1661-7649
Type: Journal Article
Subjects: HIV
Prostate cancer
Radical prostatectomy
Systematic review
Appears in Collections:Journal articles

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