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Title: Oxygen therapy in COPD and interstitial lung disease: navigating the knowns and unknowns.
Austin Authors: Khor, Yet H ;Renzoni, Elisabetta A;Visca, Dina;McDonald, Christine F ;Goh, Nicole S L 
Affiliation: School of Medicine, University of Melbourne, Melbourne, Australia
Interstitial Lung Disease Unit, Royal Brompton Hospital, Imperial College London, London, UK
Respiratory and Sleep Medicine
Institute for Breathing and Sleep
Dept of Respiratory Medicine, Alfred Health, Melbourne, Australia
Division of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, IRCCS, Tradate, Italy Dept of Medicine and Surgery, Respiratory Diseases, University of Insubria, Varese-Como, Italy
Issue Date: Jul-2019
Date: 2019
Publication information: ERJ Open Research 2019; 5(3): 00118-2019
Abstract: Domiciliary oxygen therapy is often prescribed for patients with hypoxaemia due to advanced lung disease, most commonly chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). Long-term oxygen therapy (LTOT) trials conducted in patients with COPD in the 1980s remain the basis for clinical decisions and guideline recommendations regarding LTOT for patients with non-COPD conditions as there is a lack of high-quality evidence concerning its use in the non-COPD population. There is also a lack of evidence for the use of ambulatory and nocturnal oxygen therapy in patients with isolated exertional and nocturnal hypoxaemia. These deficiencies pose significant challenges in patient care, with consequent discrepancies in guideline recommendations and clinical approaches. In recent years, new studies have been and are currently being conducted to fill the gaps in our understanding and use of domiciliary oxygen therapy for other indications, including ILD. This article provides a comparison of the epidemiology and significance of hypoxaemia in patients with COPD and ILD, with an up-to-date review of current evidence regarding the role of different types of domiciliary oxygen therapy in these conditions.
DOI: 10.1183/23120541.00118-2019
ORCID: 0000-0002-5434-9342
Journal: ERJ Open Research
PubMed URL: 31544111
ISSN: 2312-0541
Type: Journal Article
Appears in Collections:Journal articles

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