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Title: Associations between Sleep and Verbal Memory in Subjective Cognitive Decline: A Role for Semantic Clustering.
Austin Authors: Manousakis, Jessica E;Nicholas, Christian L;Scovelle, Anna J;Hons, BPsych;Naismith, Sharon L;Anderson, Clare
Affiliation: National Health and Medical Research Council, Centre of Research Excellence 'Neurosleep'
Healthy Brain Ageing Program, Brain and Mind Centre, The University of Sydney, Sydney, Australia
School of Psychology, Charles Perkins Centre, The University of Sydney, Sydney, Australia
Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Victoria, Australia
Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia
Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia
Issue Date: Dec-2019 2019-09-03
Publication information: Neurobiology of learning and memory 2019; 166: 107086
Abstract: Age-related reductions in slow wave activity (SWA) and increased fragmentation during sleep play a key role in memory impairment. As the prefrontal cortex is necessary for the control processes relevant to memory encoding, including utilisation of internal heuristics such as semantic clustering, and is preferentially vulnerable to sleep disturbance, our study examined how SWA and sleep fragmentation relates to memory performance in individuals with Subjective Cognitive Decline (SCD). Thirty older adults with SCD (Mean Age = 69.34, SD = 5.34) completed an extensive neurocognitive test battery, including the California Verbal Learning Test, which was used to assess semantic clustering. One week later, participants were admitted to the laboratory for a two night visit. SWA and sleep fragmentation were captured using sleep polysomnography. Next-day memory performance was tested using the Rey Auditory Verbal Learning Test. Poorer sleep (reduced SWA; increased arousals) was associated with reduced semantic clustering, which mediated impairment on verbal memory and learning tests conducted both the day after sleep was recorded (for both SWA and arousals), and a week prior (for arousals only). We demonstrate semantic clustering mediated the well described associations between sleep and verbal memory. As these strategies are a component of cognitive training interventions, future research may examine the role of simultaneous sleep interventions for improving cognitive training outcomes.
DOI: 10.1016/j.nlm.2019.107086
PubMed URL: 31491555
Type: Journal Article
Subjects: Slow wave sleep
circadian timing
declarative memory
mnemonic tools
sleep fragmentation
strategy use
Appears in Collections:Journal articles

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