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Title: Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores.
Austin Authors: Goodin, Peter;Lamp, Gemma;Vidyasagar, Rishma;Connelly, Alan;Rose, Stephen;Campbell, Bruce C V;Tse, Tamara ;Ma, Henry;Howells, David;Hankey, Graeme J;Davis, Stephen;Donnan, Geoffrey;Carey, Leeanne M 
Affiliation: Advanced Imaging, Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre-Austin Campus, Heidelberg, Victoria, Australia
Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, Parkville, Melbourne, Victoria, Australia
Occupational Therapy, School of Allied Health, Human Services and Sport, College of Science, Health and Engineering, La Trobe University, Bundoora, Victoria, Australia
Medical School, University of Western Australia, Perth, Western Australia, Australia
Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia
Australian e-Health Research Centre, CSIRO, Brisbane, Queensland, Australia
Department of Florey, University of Melbourne, Parkville, Victoria, Australia
School of Medicine, University of Tasmania, Australia
Neurorehabilitation and Recovery, Stroke, The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
Issue Date: 28-Jul-2019 2019-07-28
Publication information: Neural plasticity 2019; 2019: 2357107
Abstract: One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of function and cognition, yet our understanding of potential mechanisms is currently limited. Alterations in resting-state functional MRI have been investigated to a limited extent. Fluctuations in low frequency signal are reported, but it is unknown if interactions are present between the level of depressive symptom score and intrinsic brain activity in varying brain regions. To investigate potential interaction effects between whole-brain resting-state activity and depressive symptoms in stroke survivors with low and high levels of depressive symptoms. A cross-sectional analysis of 63 stroke survivors who were assessed at 3 months poststroke for depression, using the Montgomery-Åsberg Depression Rating Scale (MÅDRS-SIGMA), and for brain activity using fMRI. A MÅDRS-SIGMA score of >8 was classified as high depressive symptoms. Fractional amplitude of frequency fluctuations (fALFF) data across three frequency bands (broadband, i.e., ~0.01-0.08; subbands, i.e., slow-5: ~0.01-0.027 Hz, slow-4: 0.027-0.07) was examined. Of the 63 stroke survivors, 38 were classified as "low-depressive symptoms" and 25 as "high depressive symptoms." Six had a past history of depression. We found interaction effects across frequency bands in several brain regions that differentiated the two groups. The broadband analysis revealed interaction effects in the left insula and the left superior temporal lobe. The subband analysis showed contrasting fALFF response between the two groups in the left thalamus, right caudate, and left cerebellum. Across the three frequency bands, we found contrasting fALFF response in areas within the fronto-limbic-thalamic network and cerebellum. We provide evidence that fALFF is sensitive to changes in poststroke depressive symptom severity and implicates frontostriatal and cerebellar regions, consistent with previous studies. The use of multiband analysis could be an effective method to examine neural correlates of depression after stroke. The START-PrePARE trial is registered with the Australian New Zealand Clinical Trial Registry, number ACTRN12610000987066.
DOI: 10.1155/2019/2357107
ORCID: 0000-0002-7136-5037
Journal: Neural plasticity
PubMed URL: 31467520
Type: Journal Article
Appears in Collections:Journal articles

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