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Title: A laboratory-derived early warning score for the prediction of in-hospital mortality, ICU admission, Medical Emergency Team activation and Cardiac Arrest in general medical wards.
Austin Authors: Ratnayake, Hasanka;Johnson, Douglas;Martensson, Johan;Lam, Que;Bellomo, Rinaldo 
Affiliation: Data Analytics Research and Evaluation (DARE) Centre, Austin Health and The University of Melbourne, Heidelberg, Victoria, Australia
Department of General Medicine, Royal Melbourne Hospital, Melbourne, Australia
Department of Aged Care, Alfred Hospital, Melbourne, Australia
Department of Pathology, Austin Health, Heidelberg, Victoria, Australia
Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Issue Date: 19-Aug-2019
Date: 2019-08-19
Publication information: Internal Medicine Journal 2019; online first: 19 August
Abstract: To assess whether a laboratory based admission score can predict in hospital mortality, ICU admission, Medical Emergency Team (MET) activation or cardiac arrest in a cohort of Australian general medical patients admitted via the emergency department. We performed a retrospective observational study of all general medical admissions to hospital via the emergency department in 2015. Admission pathology was used to calculate a risk score. In-patient outcomes of death, ICU transfer, MET Call activation or cardiac arrest were collected from hospital records. We studied 2942 admissions derived from 2521 patients, with a median age of 81 years. There were 143 in-patient deaths, 82 ICU admissions, 277 MET Calls and 14 cardiac arrest calls. The laboratory-based admission score had an area under the receiver operating characteristic curve (AUC-ROC) of 0.76 (95%CI: 0.72-0.80) for inpatient death, an AUC-ROC of 0.79 (95%CI: 0.66-0.93) for inpatient cardiac arrest, an AUC-ROC of 0.64 (95%CI:0.58-0.70) for ICU transfer and an AUC-ROC of 0.59 (95%CI:0.55-0.62) for MET Call activation. When patients aged over 75 were analysed separately, the AUC-ROC for prediction of in-patient death was 0.74 (95%CI: 0.70-0.78) and increased to 0.86 (95%CI: 0.73-0.98) for the prediction of in-patient cardiac arrest. A simple laboratory derived score obtained at patient admission is a fair to good predictor of subsequent in-patient death or cardiac arrest in general medical patients and in the older patient cohort. Prospective interventional studies are required to ascertain the clinical utility of this admission score. This article is protected by copyright. All rights reserved.
DOI: 10.1111/imj.14613
ORCID: 0000-0002-0197-8356
Journal: Internal Medicine Journal
PubMed URL: 31424605
Type: Journal Article
Appears in Collections:Journal articles

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