Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWang, Xiao-Fang-
dc.contributor.authorGhasem-Zadeh, Ali-
dc.contributor.authorZhou, Bin-
dc.contributor.authorGuo, X Edward-
dc.contributor.authorZhang, Zhendong-
dc.contributor.authorSeeman, Ego-
dc.identifier.citationBone 2019; 128: 115039en_US
dc.description.abstractAppendicular fractures are less common in Chinese than Caucasian women. Bone mineral density (BMD) is lower, not higher than in Caucasians because Chinese have smaller appendicular dimensions than Caucasians. However, smaller bones may offset the liability to fracture by being assembled with a more robust microstructure. We hypothesized that Chinese assemble an appendicular skeleton with a thicker, less porous and more mineralized cortex that is less deteriorated in advanced age than in Caucasians. We compared anthropometry in 477 Chinese and 278 Caucasian women and compared bone microstructure using high-resolution peripheral quantitative computed tomography in another cohort of 186 Chinese and 381 Caucasian women aged 18 to 86 years, all living in Melbourne, Australia. Trabecular plate (p) and rod (r) bone volume/total volume (BV/TV) were quantified using individual trabecula segmentation (ITS). Bone strength was estimated using micro-finite element analysis (μFEA). Premenopausal Chinese were shorter than Caucasian women, mainly due to shorter leg length. Distal radial total cross sectional area (CSA) was 14.8% smaller (p < 0.001). After adjusting for age and total CSA, Chinese had similar cortical and medullary areas but 0.30 SD lower cortical porosity and 0.27 SD higher matrix mineral density (both p < 0.05). Trabecular plate-to-rod ratio was 0.55 SD higher due to a 0.41 SD higher pBV/TV and 0.36 SD lower rBV/TV (p ranging 0.001 to 0.023). Chinese also had 0.36 SD greater whole bone stiffness and 0.36 SD greater failure load than Caucasians (both p < 0.05). After adjusting for age and total CSA, postmenopausal Chinese had 3.3% smaller cortical area, medullary area was 2.1% larger, cortical porosity was no lower, matrix mineral density and pBV/TV were no higher compared with Caucasians at the distal radius. Whole bone stiffness was 0.39 SD lower and failure load was 0.40 SD lower in Chinese (both p < 0.05). Chinese build a more robust skeleton than Caucasians during growth, an advantage not observed in advanced age due to greater bone loss or race-specific secular trends in bone morphology.en_US
dc.subjectBone microstructureen_US
dc.subjectRacial dimorphismen_US
dc.titleDimorphism in axial and appendicula dimensions, cortical and trabecular microstructure and matrix mineral density in Chinese and Caucasian women.en_US
dc.typeJournal Articleen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.affiliationMary MacKillop Institute of Heathly Aging, Australian Catholic University, Melbourne, Australiaen_US
dc.identifier.affiliationBone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USAen_US
dc.type.austinJournal Article-, Ali
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

checked on May 27, 2024

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.