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Title: Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Transplant Recipients.
Austin Authors: Sasadeusz, Joe;Grigg, Andrew P ;Hughes, Peter D;Lee Lim, Seng;Lucas, Michaela;McColl, Geoff;McLachlan, Sue Anne;Peters, Marion G;Shackel, Nicholas;Slavin, Monica;Sundararajan, Vijaya;Thompson, Alexander;Doyle, Joseph;Rickard, James;De Cruz, Peter;Gish, Robert G;Visvanathan, Kumar
Affiliation: Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
University of California, San Francisco, S357 Parnassus Avenue, San Francisco, CA 94143, USA
University of Queensland Oral Health Centre, 288 Herston Road, Queensland 4006, Australia
Ingham Institute, 1 Campbell Street, Liverpool, Sydney, New South Wales 2170, Australia
Victorian Comprehensive Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia
Department of Public Health, La Trobe University, Plenty Road, Bundoora, Victoria 3086, Australia
Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia
The Alfred and Monash University, 85 Commercial Road, Melbourne, Victoria 3004, Australia
University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia
Peter Doherty Institute for Infection and Immunity, Elizabeth Street, Melbourne, Victoria 3000, Australia
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
St Vincent's Hospital, 41 Victoria Street, Fitzroy, Victoria 3065, Australia
Royal Melbourne Hospital, 300 Grattan Street, Parkville, Victoria 3050, Australia
National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077, Singapore
Issue Date: Aug-2019 2019-06-06
Publication information: Clinics in liver disease 2019; 23(3): 493-509
Abstract: Organ transplantation is a lifesaving procedure for many patients. To prevent rejection or graft-versus-host disease, recipients require long-term immunosuppression. In patients who have ever been exposed to hepatitis B, it is possible for reactivation to occur; this includes patients who are anti-hepatitis B core antibody-positive only or both anti-hepatitis B core antibody-positive and hepatitis B surface antibody-positive. The susceptibility to this varies with the nature of the transplant. Hepatitis B can be transmitted from donor to recipient. It is important to assess the hepatitis B status and formulate a strategy to prevent transmission and prevent reactivation.
DOI: 10.1016/j.cld.2019.04.010
PubMed URL: 31266623
Type: Journal Article
Subjects: Hepatitis B
Appears in Collections:Journal articles

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