Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Transplant Recipients.

2019-08

Sasadeusz, Joe

Grigg, Andrew P

Hughes, Peter D

Lee Lim, Seng

Lucas, Michaela

McColl, Geoff

McLachlan, Sue Anne

Peters, Marion G

Shackel, Nicholas

Slavin, Monica

Sundararajan, Vijaya

Thompson, Alexander

Doyle, Joseph

Rickard, James

De Cruz, Peter

Gish, Robert G

Visvanathan, Kumar

Hepatitis B

Prophylaxis

Reactivation

Transmission

Transplantation

Journal Article

10.1016/j.cld.2019.04.010

Organ transplantation is a lifesaving procedure for many patients. To prevent rejection or graft-versus-host disease, recipients require long-term immunosuppression. In patients who have ever been exposed to hepatitis B, it is possible for reactivation to occur; this includes patients who are anti-hepatitis B core antibody-positive only or both anti-hepatitis B core antibody-positive and hepatitis B surface antibody-positive. The susceptibility to this varies with the nature of the transplant. Hepatitis B can be transmitted from donor to recipient. It is important to assess the hepatitis B status and formulate a strategy to prevent transmission and prevent reactivation.

link

Clinics in liver disease 2019; 23(3): 493-509

Clinics in liver disease