Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/21492
Title: COO and MYC/BCL2 status do not predict outcome among patients with stage I/II DLBCL: a retrospective multicenter study.
Austin Authors: Barraclough, Allison ;Alzahrani, Musa;Ettrup, Marianne Schmidt;Bishton, Mark;van Vliet, Chris;Farinha, Pedro;Gould, Clare;Birch, Simone;Sehn, Laurie H;Sovani, Vishakha;Ward, Mitchell Steven;Augustson, Bradley;Biccler, Jorne;Connors, Joseph M;Scott, David W;Gandhi, Maher K;Savage, Kerry J;El-Galaly, Tarec;Villa, Diego;Cheah, Chan Yoon
Affiliation: Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
Department of Hematology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
Department of Haematology, Austin Health, Melbourne, Victoria, Australia
Department of Haematology, Nottingham City Hospital, Nottingham, United Kingdom
Haematology Malignancy Diagnostic Service, Nottingham City Hospital, Nottingham, United Kingdom
Department of Haematology, Medical School, University of Western Australia, Perth, WA, Australia
Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada
Department of Pathology and Laboratory Medicine and Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada
Department of Haematology, Princess Alexandra Hospital, Brisbane, QLD, Australia
Department of Haematology, Sir Charles Gairdner Hospital, Perth, WA, Australia
University of Queensland Diamantina Institute, Brisbane, QLD, Australia
Department of Anatomical Pathology, PathWest QEII Medical Centre WA, Perth, WA, Australia
Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, QLD, Australia
Department of Anatomical Pathology, Pathology Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia
Hollywood Private Hospital, Perth, WA, Australia
Department of Haematology, PathWest QEII Medical Centre WA, Perth, WA, Australia
Department of Pathology, Aalborg University Hospital, Aalborg, Denmark
Department of Haematology, Aalborg University Hospital, Aalborg, Denmark
Issue Date: 9-Jul-2019
Publication information: Blood advances 2019; 3(13): 2013-2021
Abstract: In advanced-stage diffuse large B-cell lymphoma (DLBCL), the presence of an activated B-cell phenotype or a non-germinal center (GCB) phenotype, coexpression of MYC and BCL2 by immunohistochemistry, and the cooccurrence of MYC and BCL2 or BCL6 rearrangements are associated with inferior outcomes. It is unclear whether these variables remain prognostic in stage I/II patients. In this retrospective study, we evaluated the prognostic impact of cell of origin (COO), as well as dual-expressor (DE) status and molecular double-hit (DH) status, in stage I/II DLBCL by positron emission tomography with computed tomography (PET-CT). A total of 211 patients treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone)-like regimens, with or without radiotherapy, was included. The median follow-up in the entire cohort was 4 years (range, 0.4-9.4), with estimated 4-year progression-free survival (PFS) and overall survival (OS) rates of 85% (95% confidence interval [CI], 79-89) and 88% (95% CI, 83-92), respectively. By univariable analysis, DE (PFS: hazard ratio [HR], 1.27; 95% CI, 0.58-2.81, P = .55 and OS: HR, 1.40; 95% CI, 0.60-3.30; P = .44), DH (PFS: HR, 1.21; 95% CI, 0.27-5.31; P = .80 and OS: HR, 0.61; 95% CI, 0.08-4.73; P = .64), and non-GCB status (PFS: HR, 1.59; 95% CI, 0.83-3.03; P = .16 and OS: HR, 1.80; 95% CI, 0.89-3.67; P = .10) were associated with poorer outcomes. In patients with PET-CT-defined stage I/II DLBCL treated with R-CHOP-like therapy, with or without radiation, COO and DE and DH status were not significantly associated with inferior PFS or OS.
URI: http://ahro.austin.org.au/austinjspui/handle/1/21492
DOI: 10.1182/bloodadvances.2019000251
ORCID: 0000-0001-6058-1036
0000-0001-9364-9391
0000-0002-3043-9503
0000-0003-1000-5393
0000-0002-4406-380X
0000-0002-4625-3009
0000-0001-7988-1565
PubMed URL: 31285189
Type: Journal Article
Appears in Collections:Journal articles

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