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Title: Effect of a 24-month physical activity program on brain changes in older adults at risk of Alzheimer's disease: the AIBL active trial.
Austin Authors: Venkatraman, Vijay K;Sanderson, Andrew;Cox, Kay L;Ellis, Kathryn A;Steward, Christopher;Phal, Pramit M;Gorelik, Alexandra;Sharman, Matthew J;Villemagne, Victor L ;Lai, Michelle;Cyarto, Elizabeth V;Merkel, Bernd;Ames, David;Szoeke, Cassandra;Rowe, Christopher C ;Masters, Colin L ;Lautenschlager, Nicola T;Desmond, Patricia M
Affiliation: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia
NorthWestern Mental Health, Melbourne Health, Melbourne, Victoria, Australia
Melbourne Dementia Research Centre, University of Melbourne, Melbourne, Australia
Department of Medicine and Radiology, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia
National Ageing Research Institute, Melbourne, Victoria, Australia
Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia
Melbourne EpiCenter, Royal Melbourne Hospital, Melbourne, Australia
Medical School, University of Western Australia, Perth, Australia
Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
School of Health Sciences, University of Tasmania, Launceston, Australia
Issue Date: May-2020
Date: 2019-05-27
Publication information: Neurobiology of aging 2020; 89: 132-141
Abstract: White matter hyperintensities (WMHs) are a risk factor for cognitive decline. Physical activity (PA) is associated with lower WMH. Whether long-term exposure to PA programs has beneficial effects on WMH progression in older adults with memory complaints and comorbid conditions has had limited exploration. This study explored whether a 24-month moderate-intensity PA intervention can delay the progression of WMH and hippocampus loss in older adults at risk for cognitive decline. Data acquired on magnetic resonance imaging were used to measure the progression of WMH and hippocampus loss. The results of this study showed no effect of intervention on either the primary outcome measure "WMH" or the secondary outcome measure "hippocampal volume." In addition, neither beta amyloid status nor the adherence to the intervention had any effect on the outcome. In this cohort of subjective memory complaints and mild cognitive impairment participants with vascular risk factors, there was no effect of long-term moderate-intensity PA on WMH or hippocampal loss.
DOI: 10.1016/j.neurobiolaging.2019.02.030
Journal: Neurobiology of aging
PubMed URL: 31324405
Type: Journal Article
Subjects: Cognitive impairment
Hippocampal loss
Physical activity
White matter hyperintensity
Appears in Collections:Journal articles

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