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Title: Four-repeat tauopathies.
Austin Authors: Rösler, Thomas W;Tayaranian Marvian, Amir;Brendel, Matthias;Nykänen, Niko-Petteri;Höllerhage, Matthias;Schwarz, Sigrid C;Hopfner, Franziska;Koeglsperger, Thomas;Respondek, Gesine;Schweyer, Kerstin;Levin, Johannes;Villemagne, Victor L ;Barthel, Henryk;Sabri, Osama;Müller, Ulrich;Meissner, Wassilios G;Kovacs, Gabor G;Höglinger, Günter U
Affiliation: Dept. of Neurology, Hannover Medical School, 30625 Hannover, Germany
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Dept. of Neurology, University of Munich, 81377 Munich, Germany
German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany
Dept. of Neurology, Technical University of Munich, School of Medicine, 81675 Munich, Germany
Service de Neurologie, CHU Bordeaux, 33000 Bordeaux, France; Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, 33000 Bordeaux, France
CNRS, Institut des Maladies Neurodégénératives, UMR 5293, 33000 Bordeaux, France; Dept. of Medicine, University of Otago, Christchurch, New Zealand
New Zealand Brain Research Institute, Christchurch, New Zealand
Institute of Neurology, Medical University of Vienna, 1090 Vienna, Austria
Dept. of Laboratory Medicine and Pathobiology, University of Toronto, Laboratory Medicine Program, University Health Network, Toronto, Canada
Tanz Centre for Research in Neurodegenerative Disease, Krembil Brain Institute, Toronto, Canada
Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany
Dept. of Neurology, Technical University of Munich, School of Medicine, 81675 Munich, Germany.
Dept. of Molecular Imaging and Therapy, Austin Health, Heidelberg, VIC, 3084, Australia
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
Dept. of Nuclear Medicine, University of Munich, 81377 Munich, Germany.
Dept. of Psychiatry, University of Munich, 80336 Munich, Germany
Dept. of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany
Institute for Human Genetics, University of Giessen, 35392 Giessen, Germany
Issue Date: Sep-2019 2019-06-22
Publication information: Progress in neurobiology 2019; 180: 101644
Abstract: Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative diseases defined by cytoplasmic inclusions predominantly composed of tau protein isoforms with four microtubule-binding domains. Progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease or glial globular tauopathy belong to the group of 4R-tauopathies. The present review provides an introduction in the current concept of 4R-tauopathies, including an overview of the neuropathological and clinical spectrum of these diseases. It describes the genetic and environmental etiological factors, as well as the contemporary knowledge about the pathophysiological mechanisms, including post-translational modifications, aggregation and fragmentation of tau, as well as the role of protein degradation mechanisms. Furthermore, current theories about disease propagation are discussed, involving different extracellular tau species and their cellular release and uptake mechanisms. Finally, molecular diagnostic tools for 4R-tauopathies, including tau-PET and fluid biomarkers, and investigational therapeutic strategies are presented. In summary, we report on 4R-tauopathies as overarching disease concept based on a shared pathophysiological concept, and highlight the challenges and opportunities on the way towards a causal therapy.
DOI: 10.1016/j.pneurobio.2019.101644
PubMed URL: 31238088
Type: Journal Article
Subjects: 4R-tauopathy
Alzheimer’s disease
Argyrophilic grain disease
Corticobasal degeneration
Glial globular tauopathy
Microtubule-Associated protein tau
Progressive supranuclear palsy
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